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Secondary metabolite arsenal of an opportunistic pathogenic fungus.
Bignell, Elaine; Cairns, Timothy C; Throckmorton, Kurt; Nierman, William C; Keller, Nancy P.
Afiliación
  • Bignell E; Manchester Fungal Infection Group, Institute of Inflammation and Repair, 2.24 Core Technology Facility, Grafton Street, Manchester, M13 9NT, UK.
  • Cairns TC; Department of Applied and Molecular Microbiology, Institute of Biotechnology, Berlin University of Technology, Gustav-Meyer-Allee 25, 13355 Berlin, Germany.
  • Throckmorton K; Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA.
  • Nierman WC; The J. Craig Venter Institute, Rockville, MD 20850, USA.
  • Keller NP; Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA, npkeller@wisc.edu.
Philos Trans R Soc Lond B Biol Sci ; 371(1709)2016 12 05.
Article en En | MEDLINE | ID: mdl-28080993
Aspergillus fumigatus is a versatile fungus able to successfully exploit diverse environments from mammalian lungs to agricultural waste products. Among its many fitness attributes are dozens of genetic loci containing biosynthetic gene clusters (BGCs) producing bioactive small molecules (often referred to as secondary metabolites or natural products) that provide growth advantages to the fungus dependent on environment. Here we summarize the current knowledge of these BGCs-18 of which can be named to product-their expression profiles in vivo, and which BGCs may enhance virulence of this opportunistic human pathogen. Furthermore, we find extensive evidence for the presence of many of these BGCs, or similar BGCs, in distantly related genera including the emerging pathogen Pseudogymnoascus destructans, the causative agent of white-nose syndrome in bats, and suggest such BGCs may be predictive of pathogenic potential in other fungi.This article is part of the themed issue 'Tackling emerging fungal threats to animal health, food security and ecosystem resilience'.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aspergilosis / Aspergillus fumigatus / Familia de Multigenes Idioma: En Revista: Philos Trans R Soc Lond B Biol Sci Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aspergilosis / Aspergillus fumigatus / Familia de Multigenes Idioma: En Revista: Philos Trans R Soc Lond B Biol Sci Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido