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The impact of pH inhomogeneities on CHO cell physiology and fed-batch process performance - two-compartment scale-down modelling and intracellular pH excursion.
Brunner, Matthias; Braun, Philipp; Doppler, Philipp; Posch, Christoph; Behrens, Dirk; Herwig, Christoph; Fricke, Jens.
Afiliación
  • Brunner M; Research Division Biochemical Engineering, Institute of Chemical Engineering, Vienna University of Technology, Vienna, Austria.
  • Braun P; CD Laboratory on Mechanistic and Physiological Methods for Improved Bioprocesses, Vienna University of Technology, Vienna, Austria.
  • Doppler P; Research Division Biochemical Engineering, Institute of Chemical Engineering, Vienna University of Technology, Vienna, Austria.
  • Posch C; CD Laboratory on Mechanistic and Physiological Methods for Improved Bioprocesses, Vienna University of Technology, Vienna, Austria.
  • Behrens D; Research Division Biochemical Engineering, Institute of Chemical Engineering, Vienna University of Technology, Vienna, Austria.
  • Herwig C; CD Laboratory on Mechanistic and Physiological Methods for Improved Bioprocesses, Vienna University of Technology, Vienna, Austria.
  • Fricke J; Sandoz GmbH, Langkampfen, Austria.
Biotechnol J ; 12(7)2017 Jul.
Article en En | MEDLINE | ID: mdl-28078826
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células CHO / Técnicas de Cultivo Celular por Lotes Límite: Animals Idioma: En Revista: Biotechnol J Asunto de la revista: BIOTECNOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células CHO / Técnicas de Cultivo Celular por Lotes Límite: Animals Idioma: En Revista: Biotechnol J Asunto de la revista: BIOTECNOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Alemania