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Iodine nutritional status and thyroid effects of exposure to ethylenebisdithiocarbamates.
Medda, Emanuela; Santini, Ferruccio; De Angelis, Simona; Franzellin, Fabrizio; Fiumalbi, Carla; Perico, Andrea; Gilardi, Enzo; Mechi, Maria Teresa; Marsili, Alessandro; Citroni, Angela; Leandri, Adaniele; Mantovani, Alberto; Vitti, Paolo; Olivieri, Antonella.
Afiliación
  • Medda E; National Centre for Epidemiology Surveillance and Health Promotion, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy.
  • Santini F; Endocrinology Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
  • De Angelis S; Department of Cell Biology and Neuroscience, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy.
  • Franzellin F; Nuclear Medicine of Bolzano Hospital, Bolzano, Italy.
  • Fiumalbi C; Department of Prevention, ASL Firenze, Italy.
  • Perico A; Public Health Laboratory, ASL Firenze, Italy.
  • Gilardi E; Department of Cell Biology and Neuroscience, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy.
  • Mechi MT; Department of Prevention, ASL Firenze, Italy.
  • Marsili A; Endocrinology Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
  • Citroni A; Department of Prevention, ASL Firenze, Italy.
  • Leandri A; Public Health Laboratory, ASL Firenze, Italy.
  • Mantovani A; Department of Food Safety and Veterinary Public Health, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy.
  • Vitti P; Endocrinology Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
  • Olivieri A; Department of Cell Biology and Neuroscience, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: antonella.olivieri@iss.it.
Environ Res ; 154: 152-159, 2017 04.
Article en En | MEDLINE | ID: mdl-28073049
INTRODUCTION: Italy is still characterized by a mild iodine deficiency and is among the most intensive users of chemical products for agriculture in Europe. The aim of this study was i) to evaluate thyroid effects of exposure to mancozeb, a fungicide widely used in agriculture, in a sample of Italian grapevine workers, and ii) to verify whether the iodine intake may modulate the risk of thyroid disruption due to the mancozeb metabolite ethylenthiourea (ETU). METHODS: One hundred seventy-seven occupationally exposed male workers (29 from Chianti, a mild iodine deficient area, and 148 from Bolzano an iodine sufficient province) and 74 non-occupationally exposed male controls (34 from Chianti and 40 from Bolzano) were enrolled in the study. Serum biomarkers of thyroid function, as well as urinary iodine and ETU concentrations were assessed. Moreover all the recruited subjects underwent clinical examination and thyroid ultrasound. RESULTS: Multivariate comparisons showed lower mean serum levels of FT4 in Chianti-workers as compared to Bolzano-workers. Moreover, an increased urinary iodine excretion (>250µg/L) was more frequently found among more exposed workers (ETU>20µg/L) than among less exposed ones and this effect was more pronounced in Chianti- than in Bolzano-workers. Chianti-workers also showed a significantly higher frequency of very low thyroid volume (≤6.0ml) as compared to controls. CONCLUSIONS: These findings showed a mild thyroid disrupting effect due to occupational exposure to mancozeb, more pronounced in workers residing in an area characterized by a mild to moderate iodine deficiency as compared to workers residing in an area covered by a long-lasting iodine prophylaxis program.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Tiroides / Zineb / Fungicidas Industriales / Yodo / Maneb Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Environ Res Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Tiroides / Zineb / Fungicidas Industriales / Yodo / Maneb Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Environ Res Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos