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A study of oxidative stress in neonates delivered through meconium-stained amniotic fluid.
Bandyopadhyay, Tapas; Bhatia, B D; Khanna, H D.
Afiliación
  • Bandyopadhyay T; Department of Pediatrics, Institute of Medical Sciences, B.H.U, Vanarasi, India. dr.tapasbanerjee@gmail.com.
  • Bhatia BD; Department of Pediatrics, Institute of Medical Sciences, B.H.U, Vanarasi, India.
  • Khanna HD; Department of Biophysics, Institute of Medical Sciences, B.H.U, Vanarasi, India.
Eur J Pediatr ; 176(3): 317-325, 2017 Mar.
Article en En | MEDLINE | ID: mdl-28062958
To estimate the levels of malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OH-dG) in cord blood plasma of newborns born through meconium-stained amniotic fluid (MSAF) and also to find out the correlation between their levels with birth weight and gestation, we measured the cord blood plasma levels of MDA and 8-OH-dG in 59 newborns born through MSAF and 50 newborns born through clear liquor. The levels of cord blood plasma MDA and 8-OH-dG were significantly higher in full-term and late-preterm newborns born through MSAF. On further comparison, it was found that both full-term and late-preterm intrauterine growth restricted (IUGR) neonates had higher levels of these markers as compared to babies born as appropriate for gestational age (AGA) through MSAF. Plasma levels of MDA and 8-OH-dG were significantly correlated with birth weight even after controlling the relationship with gestational age for all cases as well as all full-term cases. These markers are also significantly correlated to each other. CONCLUSIONS: The present study suggest that the neonates born through MSAF experience higher degrees of oxidative stress, as evidenced by increased levels of cord blood plasma MDA and 8-OH-dG. What is known: • Aspirated meconium has been found to induce free radical generation and cellular damage in animal studies. • Its role in free radical generation and oxidative damage in human neonates is scarce. What is new: • Neonates born through meconium-stained amniotic fluid experience significant oxidative stress.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Parto Obstétrico / Sangre Fetal / Líquido Amniótico / Meconio Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Eur J Pediatr Año: 2017 Tipo del documento: Article País de afiliación: India Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Parto Obstétrico / Sangre Fetal / Líquido Amniótico / Meconio Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Eur J Pediatr Año: 2017 Tipo del documento: Article País de afiliación: India Pais de publicación: Alemania