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Heterogeneity of blood flow and metabolism during exercise in patients with chronic obstructive pulmonary disease.
Louvaris, Zafeiris; Habazettl, Helmut; Asimakos, Andreas; Wagner, Harrieth; Zakynthinos, Spyros; Wagner, Peter D; Vogiatzis, Ioannis.
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  • Louvaris Z; Faculty of Physical Education and Sport Sciences, National and Kapodistrian University of Athens, Greece; 1st Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, "M. Simou, and G.P. Livanos Laboratories", National and Kapodistrian University of Athens, Greece; Faculty
  • Habazettl H; Institute of Physiology, Charité Campus Benjamin Franklin, Berlin, Germany; Institute of Anesthesiology, Deutsches Herzzentrum Berlin, Germany.
  • Asimakos A; 1st Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, "M. Simou, and G.P. Livanos Laboratories", National and Kapodistrian University of Athens, Greece.
  • Wagner H; Department of Medicine, University of California San Diego, La Jolla, CA, USA.
  • Zakynthinos S; 1st Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, "M. Simou, and G.P. Livanos Laboratories", National and Kapodistrian University of Athens, Greece.
  • Wagner PD; Department of Medicine, University of California San Diego, La Jolla, CA, USA.
  • Vogiatzis I; Faculty of Physical Education and Sport Sciences, National and Kapodistrian University of Athens, Greece; 1st Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, "M. Simou, and G.P. Livanos Laboratories", National and Kapodistrian University of Athens, Greece; Departm
Respir Physiol Neurobiol ; 237: 42-50, 2017 03.
Article en En | MEDLINE | ID: mdl-28057577
The study investigated whether the capacity to regulate muscle blood flow (Q) relative to metabolic demand (VO2) is impaired in COPD. Using six NIRS optodes over the upper, middle and lower vastus lateralis in 6 patients, (FEV1:46±12%predicted) we recorded from each: a) Q by indocyanine green dye injection, b) VO2/Q ratios based on fractional tissue O2 saturation and c) VO2 as their product, during constant-load exercise (at 20%, 50% and 80% of peak capacity) in normoxia and hyperoxia (FIO2:1.0). At 50 and 80%, relative dispersion (RD) for Q, but not for VO2, was greater in normoxia (0.67±0.07 and 0.79±0.08, respectively) compared to hyperoxia (0.57±0.12 and 0.72±0.07, respectively). In both conditions, RD for VO2 and Q significantly increased throughout exercise; however, RD of VO2/Q ratio was minimal (normoxia: 0.12-0.08 vs hyperoxia: 0.13-0.09). Muscle Q and VO2 appear closely matched in COPD patients, indicating a minimal impact of heterogeneity on muscle oxygen availability at submaximal levels of exercise.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flujo Sanguíneo Regional / Ejercicio Físico / Músculo Esquelético / Enfermedad Pulmonar Obstructiva Crónica Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Physiol Neurobiol Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flujo Sanguíneo Regional / Ejercicio Físico / Músculo Esquelético / Enfermedad Pulmonar Obstructiva Crónica Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Physiol Neurobiol Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos