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Anti-diabetic activities of cis- and trans-2,3,5,4'-tetrahydroxystilbene 2-O-ß-glucopyranoside from Polygonum multiflorum.
Tang, Wenping; Li, Shiming; Liu, Yue; Wu, Jia-Ching; Pan, Min-Hsiung; Huang, Mou-Tuan; Ho, Chi-Tang.
Afiliación
  • Tang W; Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization; College of Life Science, Huanggang Normal University, Huanggang, China.
  • Li S; Department of Food Science, Rutgers-The State University of New Jersey, New Brunswick, NJ, USA.
  • Liu Y; Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization; College of Life Science, Huanggang Normal University, Huanggang, China.
  • Wu JC; Department of Chemical Biology, Rutgers-The State University of New Jersey, Piscataway, NJ, USA.
  • Pan MH; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
  • Huang MT; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
  • Ho CT; Department of Chemical Biology, Rutgers-The State University of New Jersey, Piscataway, NJ, USA.
Mol Nutr Food Res ; 61(8)2017 08.
Article en En | MEDLINE | ID: mdl-28054445
SCOPE: Functional foods can be used alone or in combination with existing therapies in preventing and treating type 2 diabetes (T2D). Trans-2,3,5,4'-tetrahydroxystilbene 2-O-ß-glucopyranoside (trans-THSG), a dominant bioactive compound from Polygonum multiflorum (PM)-a popular medicinal food in Asia, has attracted increasing research interests due to its strong antioxidant activity. The content of naturally occurring cis-THSG (cis-2,3,5,4'-tetrahydroxystilbene 2-O-ß-glucopyranoside) was very low in PM root, but was prepared in this study by mimicking the traditional process of PM. The anti-diabetic effects of trans- and cis-THSG were evaluated in T2D to search for more efficacious food ingredient(s). METHODS AND RESULTS: Trans-THSG was chromatographically purified from PM roots and cis-THSG was prepared with our innovative process via exposure of trans-THSG to UV-light. The anti-diabetic effects of both THSGs were tested with HFD-induced male CF-1 diabetic mice. Cis-THSG was found more effective than trans-THSG in hypoglycemic effect and in ameliorating glucose intolerance and insulin resistance. In HepG2 cells, cis-THSG also demonstrated more potent activity than trans-THSG in suppressing transcription of phosphoenopyruvate carboxykinase (PEPCK). CONCLUSION: Cis-THSG can be an enriched bioactive ingredient in PM roots from post-processing and is significantly more effective against hyperglycemia than trans-THSG. One of the effective pathways was through inhibition of PEPCK.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estilbenos / Fallopia multiflora / Glucósidos / Hipoglucemiantes Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estilbenos / Fallopia multiflora / Glucósidos / Hipoglucemiantes Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania