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2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound.
Filippopoulou, Konstantina; Papaevgeniou, Nikoletta; Lefaki, Maria; Paraskevopoulou, Anna; Biedermann, David; Kren, Vladimír; Chondrogianni, Niki.
Afiliación
  • Filippopoulou K; Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens 11635, Greece.
  • Papaevgeniou N; Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens 11635, Greece; Institute of Nutrition, Faculty of Biology and Pharmacy, Friedrich Schiller University of Jena, 25 Dornburger Str., 07743 Jena , Germany.
  • Lefaki M; Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens 11635, Greece.
  • Paraskevopoulou A; Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens 11635, Greece.
  • Biedermann D; Institute of Microbiology, Laboratory of Biotransformation, Czech Academy of Sciences, Vídenská 1083, 142 20 Prague, Czech Republic.
  • Kren V; Institute of Microbiology, Laboratory of Biotransformation, Czech Academy of Sciences, Vídenská 1083, 142 20 Prague, Czech Republic.
  • Chondrogianni N; Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens 11635, Greece. Electronic address: nikichon@eie.gr.
Free Radic Biol Med ; 103: 256-267, 2017 02.
Article en En | MEDLINE | ID: mdl-28039083
Aging is an unavoidable process characterized by gradual failure of homeostasis that constitutes a critical risk factor for several age-related disorders. It has been unveiled that manipulation of various key pathways may decelerate the aging progression and the triggering of age-related diseases. As a consequence, the identification of compounds, preferably natural-occurring, administered through diet, with lifespan-extending, anti-aggregation and anti-oxidation properties that in parallel exhibit negligible side-effects is the main goal in the battle against aging. Here we analyze the role of 2,3-dehydrosilybin A/B (DHS A/B), a minor component of silymarin used in a plethora of dietary supplements. This flavonolignan is well-known for its anti-oxidative and neuroprotective properties, among others. We demonstrate that DHS A/B confers oxidative stress resistance not only in human primary cells but also in the context of a multi-cellular aging model, namely Caenorhabditis elegans (C. elegans) where it also promotes lifespan extension. We reveal that these DHS A/B outcomes are FGT-1 and DAF-16 dependent. We additionally demonstrate the anti-aggregation properties of DHS A/B in human cells of nervous origin but also in nematode models of Alzheimer's disease (AD), eventually leading to decelerated progression of AD phenotype. Our results identify DHS A/B as the active component of silymarin extract and propose DHS A/B as a candidate anti-aging and anti-aggregation compound.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silimarina / Sustancias Protectoras / Agregación Patológica de Proteínas / Longevidad Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silimarina / Sustancias Protectoras / Agregación Patológica de Proteínas / Longevidad Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Estados Unidos