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NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection.
Marshall, Nikki B; Vong, Allen M; Devarajan, Priyadharshini; Brauner, Matthew D; Kuang, Yi; Nayar, Ribhu; Schutten, Elizabeth A; Castonguay, Catherine H; Berg, Leslie J; Nutt, Stephen L; Swain, Susan L.
Afiliación
  • Marshall NB; Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Vong AM; Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Devarajan P; Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Brauner MD; Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Kuang Y; Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Nayar R; Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Schutten EA; Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Castonguay CH; Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Berg LJ; Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Nutt SL; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; and.
  • Swain SL; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
J Immunol ; 198(3): 1142-1155, 2017 02 01.
Article en En | MEDLINE | ID: mdl-28031335
CD4 T cells can differentiate into multiple effector subsets, including ThCTL that mediate MHC class II-restricted cytotoxicity. Although CD4 T cell-mediated cytotoxicity has been reported in multiple viral infections, their characteristics and the factors regulating their generation are unclear, in part due to a lack of a signature marker. We show in this article that, in mice, NKG2C/E identifies the ThCTL that develop in the lung during influenza A virus infection. ThCTL express the NKG2X/CD94 complex, in particular the NKG2C/E isoforms. NKG2C/E+ ThCTL are part of the lung CD4 effector population, and they mediate influenza A virus-specific cytotoxic activity. The phenotype of NKG2C/E+ ThCTL indicates they are highly activated effectors expressing high levels of binding to P-selectin, T-bet, and Blimp-1, and that more of them secrete IFN-γ and readily degranulate than non-ThCTL. ThCTL also express more cytotoxicity-associated genes including perforin and granzymes, and fewer genes associated with recirculation and memory. They are found only at the site of infection and not in other peripheral sites. These data suggest ThCTL are marked by the expression of NKG2C/E and represent a unique CD4 effector population specialized for cytotoxicity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Influenza A / Linfocitos T CD4-Positivos / Infecciones por Orthomyxoviridae / Citotoxicidad Inmunológica / Subfamília C de Receptores Similares a Lectina de Células NK Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Immunol Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Influenza A / Linfocitos T CD4-Positivos / Infecciones por Orthomyxoviridae / Citotoxicidad Inmunológica / Subfamília C de Receptores Similares a Lectina de Células NK Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Immunol Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos