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[Nitrobenzofuroxane derivatives as dual action hiv-1 inhibitors]. / Proizvodnye nitrobenzofuroksanov v kachestve ingibitorov VICh-1 dvoinogo deistviia.
Korolev, S P; Pustovarova, M A; Starosotnikov, A M; Bastrakov, M A; Agapkina, Yu Yu; Shevelev, S A; Gottikh, M B.
Afiliación
  • Korolev SP; Belozeksky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
  • Pustovarova MA; Belozeksky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
  • Starosotnikov AM; Zelinsky Institute of Organic Chemistry, Moscow, Russia.
  • Bastrakov MA; Zelinsky Institute of Organic Chemistry, Moscow, Russia.
  • Agapkina YY; Belozeksky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
  • Shevelev SA; Zelinsky Institute of Organic Chemistry, Moscow, Russia.
  • Gottikh MB; Belozeksky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Biomed Khim ; 62(6): 725-728, 2016 Nov.
Article en Ru | MEDLINE | ID: mdl-28026819
Human immunodeficiency virus first type (HIV-1) is a main cause of one of the most dangerous diseases, AIDS. The search for new inhibitors of the virus still remains an urgent task. One approach to suppress the HIV infection is to use a double-acting inhibitors, i.e. inhibitors directed to two stages of the viral life cycle. The catalytic domain of HIV-1 integrase has a similar spatial organization with ribonuclease (RNase H) domain of HIV-1 reverse transcriptase, and approach aimed to create HIV-1 integrase and RNase H double-acting is very promising. In this work we synthesized a series of 6-nitrobenzofuroxane derivatives and studied their ability to inhibit two viral enzymes - integrase and RNase H HIV-1.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxadiazoles / VIH-1 / Inhibidores de la Transcriptasa Inversa / Transcriptasa Inversa del VIH Límite: Humans Idioma: Ru Revista: Biomed Khim Año: 2016 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxadiazoles / VIH-1 / Inhibidores de la Transcriptasa Inversa / Transcriptasa Inversa del VIH Límite: Humans Idioma: Ru Revista: Biomed Khim Año: 2016 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia