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Chemical Structure and Surface Modification of Dendritic Nanomaterials Tailored for Therapeutic and Diagnostic Applications.
Myung, Ja Hye; Hsu, Hao-Jui; Bugno, Jason; Tam, Kevin A; Hong, Seungpyo.
Afiliación
  • Myung JH; Departments of a Biopharmaceutical Sciences and b Bioengineering, University of Illinois, Chicago, IL, 60612, United States.
  • Hsu HJ; Departments of Biopharmaceutical Sciences and Bioengineering, University of Illinois, Chicago, IL, 60612, United States.
  • Bugno J; Departments of Biopharmaceutical Sciences and Bioengineering, University of Illinois, Chicago, IL, 60612, United States.
  • Tam KA; Departments of Biopharmaceutical Sciences and Bioengineering, University of Illinois, Chicago, IL, 60612, United States.
  • Hong S; Department of Biopharmaceutical Sciences, University of Illinois, Chicago, IL, United States.
Curr Top Med Chem ; 17(13): 1542-1554, 2017.
Article en En | MEDLINE | ID: mdl-28017148
Dendritic nanomaterials have attracted a great deal of scientific interest due to their high capacity for multifunctionalization and potential in various biomedical applications, such as drug/gene delivery and diagnostic systems. Depending on the molecular structure and starting monomers, several different types of dendrimers have been developed, including poly(amidoamine) (PAMAM), poly(propylenimine) (PPI), and poly(L-lysine) (PLL) dendrimers, in addition to modified dendritic nanomaterials, such as Janus dendrimers and dendritic block copolymers. The chemical structure and surface modification of dendritic nanomaterials have been found to play a critical role in governing their biological behaviors. In this review, we present a comprehensive overview focusing on the synthesis and chemical structures of dendrimers and modified dendritic nanomaterials that are currently being investigated for drug delivery, gene delivery, and diagnostic applications. In addition, the impact of chemical surface modification and functionalization to the dendritic nanomaterials on their therapeutic and diagnostic applications are highlighted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Técnicas de Transferencia de Gen / Técnicas y Procedimientos Diagnósticos / Nanoestructuras / Dendrímeros Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Curr Top Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Emiratos Árabes Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Técnicas de Transferencia de Gen / Técnicas y Procedimientos Diagnósticos / Nanoestructuras / Dendrímeros Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Curr Top Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Emiratos Árabes Unidos