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Changes in the inner ear structures in cystic fibrosis patients.
Pauna, Henrique F; Monsanto, Rafael C; Kurata, Natsuko; Paparella, Michael M; Cureoglu, Sebahattin.
Afiliación
  • Pauna HF; Department of Otolaryngology, Head & Neck Surgery, University of Minnesota Minneapolis, MN, USA; Department of Otolaryngology, Head and Neck Surgery, State University of Campinas/UNICAMP, Campinas, São Paulo, Brazil.
  • Monsanto RC; Department of Otolaryngology, Head & Neck Surgery, University of Minnesota Minneapolis, MN, USA; Department of Otolaryngology and Head and Neck Surgery, Banco de Olhos de Sorocaba Hospital (BOS), Sorocaba, São Paulo, Brazil.
  • Kurata N; Department of Otolaryngology, Head & Neck Surgery, University of Minnesota Minneapolis, MN, USA; Tokyo Medical and Dental University, Tokyo, Japan.
  • Paparella MM; Department of Otolaryngology, Head & Neck Surgery, University of Minnesota Minneapolis, MN, USA; Paparella Ear Head & Neck Institute, Minneapolis, MN, USA.
  • Cureoglu S; Department of Otolaryngology, Head & Neck Surgery, University of Minnesota Minneapolis, MN, USA. Electronic address: cureo003@umn.edu.
Int J Pediatr Otorhinolaryngol ; 92: 108-114, 2017 Jan.
Article en En | MEDLINE | ID: mdl-28012509
OBJECTIVE: Although prolonged use of antibiotics is very common in cystic fibrosis (CF) patients, no studies have assessed the changes in both cochlear and peripheral vestibular systems in this population. METHODS: We used human temporal bones to analyze the density of vestibular dark, transitional, and hair cells in specimens from CF patients who were exposed to several types of antibiotics, as compared with specimens from an age-matched control group with no history of ear disease or antibiotic use. Additionally, we analyzed the changes in the elements of the cochlea (hair cells, spiral ganglion neurons, and the area of the stria vascularis). Data was gathered using differential interference contrast microscopy and light microscopy. RESULTS: In the CF group, 83% of patients were exposed to some ototoxic drugs, such as aminoglycosides. As compared with the control group, the density of both type I and type II vestibular hair cells was significantly lower in all structures analyzed; the number of dark cells was significantly lower in the lateral and posterior semicircular canals. We noted a trend toward a lower number of both inner and outer cochlear hair cells at all turns of the cochlea. The number of spiral ganglion neurons in Rosenthal's canal at the apical turn of the cochlea was significantly lower; furthermore, the area of the stria vascularis at the apical turn of the cochlea was significantly smaller. CONCLUSIONS: Deterioration of cochlear and vestibular structures in CF patients might be related to their exposure to ototoxic antibiotics. Well-designed case-control studies are necessary to rule out the effect of CF itself.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Hueso Temporal / Células Ciliadas Vestibulares / Fibrosis Quística / Aminoglicósidos / Células Ciliadas Auditivas / Oído Interno Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Pediatr Otorhinolaryngol Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Irlanda
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Hueso Temporal / Células Ciliadas Vestibulares / Fibrosis Quística / Aminoglicósidos / Células Ciliadas Auditivas / Oído Interno Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Pediatr Otorhinolaryngol Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Irlanda