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Comparison of quinolone and beta-lactam resistance among Escherichia coli strains isolated from urinary tract infections.
Tayebi, Zahra; Heidari, Hamid; Kazemian, Hossein; Ghafoori, Seyed Mohammad; Boroumandi, Shahram; Houri, Hamidreza.
Afiliación
  • Tayebi Z; Microbiology Department, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
  • Heidari H; Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Kazemian H; Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
  • Ghafoori SM; Microbiology Department, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
  • Boroumandi S; Microbiology Department, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; Pars Advance and Minimally Invasive Research Center, Pars hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Houri H; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Infez Med ; 24(4): 326-330, 2016 12 01.
Article en En | MEDLINE | ID: mdl-28011969
The growing frequency of antibiotic resistances is now a universal problem. Increasing resistance to new generations of ß-lactam and quinolone antibiotics in multidrug-resistant Enterobacteriaceae isolates is considered an emergency health issue worldwide. The aim of this study was to evaluate plasmid-mediated quinolone resistance genes in ESBL-producing Escherichia coli isolated from urinary tract infections (UTIs). In our study ESBL-producing isolates were assessed by screening methods. After determination of antimicrobial susceptibility testing, detection of ESBLs and quinolone resistance genes was performed. A total of 97 ESBL-producing E. coli were determined. The bla-TEM, bla-SHV and bla-CTX-M genes were detected in 90 isolates. The bla-TEM was the most frequently detected gene (46.4%), followed by bla-SHV (31.9%) and bla-CTX-M (14.4%). The most prevalent quinolone resistance gene among ESBL-producing isolates was oqxAB which was found in 67 isolates (69.1%). The frequencies of the aac(6')-Ib-cr, qnr and qepA were 65 (67%), 8 (8.2%) and 6 (6.2%), respectively. Our data indicate that the prevalence of plasmid-mediated quinolone resistance genes in ESBL-positive isolates is increasing. The co-dissemination of PMQR and ESBL genes among E. coli isolates can be considered a threat to public health. Therefore, prescription of antibiotics against infectious disease should be managed carefully.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Urinarias / Beta-Lactamasas / Quinolonas / Resistencia betalactámica / Beta-Lactamas / Escherichia coli / Infecciones por Escherichia coli / Antibacterianos Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Infez Med Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Italia
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Urinarias / Beta-Lactamasas / Quinolonas / Resistencia betalactámica / Beta-Lactamas / Escherichia coli / Infecciones por Escherichia coli / Antibacterianos Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Infez Med Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Italia