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Local Effects on Airway Inflammation and Systemic Uptake of 5 nm PEGylated and Citrated Gold Nanoparticles in Asthmatic Mice.
Omlor, Albert J; Le, Duc D; Schlicker, Janine; Hannig, Matthias; Ewen, Raphael; Heck, Sebastian; Herr, Christian; Kraegeloh, Annette; Hein, Christina; Kautenburger, Ralf; Kickelbick, Guido; Bals, Robert; Nguyen, Juliane; Dinh, Q Thai.
Afiliación
  • Omlor AJ; Department of Experimental Pneumology and Allergology, Saarland University Faculty of Medicine, Kirrberger Str. 100, D-66421, Homburg/Saar, Germany.
  • Le DD; Department of Experimental Pneumology and Allergology, Saarland University Faculty of Medicine, Kirrberger Str. 100, D-66421, Homburg/Saar, Germany.
  • Schlicker J; Department of Experimental Pneumology and Allergology, Saarland University Faculty of Medicine, Kirrberger Str. 100, D-66421, Homburg/Saar, Germany.
  • Hannig M; Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University, Kirrberger Str. 100, D-66421, Homburg/Saar, Germany.
  • Ewen R; Department of Experimental Pneumology and Allergology, Saarland University Faculty of Medicine, Kirrberger Str. 100, D-66421, Homburg/Saar, Germany.
  • Heck S; Department of Experimental Pneumology and Allergology, Saarland University Faculty of Medicine, Kirrberger Str. 100, D-66421, Homburg/Saar, Germany.
  • Herr C; Department of Internal Medicine V, Pneumology, Allergology and Respiratory Critical Care Medicine, Saarland University Faculty of Medicine, Kirrberger Str. 100, D-66421, Homburg/Saar, Germany.
  • Kraegeloh A; INM-Leibniz Institute for New Materials, Campus D2 2, D-66123, Saarbrücken, Germany.
  • Hein C; Institute of Inorganic Solid State Chemistry, Saarland University, Campus Dudweiler, Am Markt Zeile 3-5, D-66125, Saarbrücken, Germany.
  • Kautenburger R; Institute of Inorganic Solid State Chemistry, Saarland University, Campus Dudweiler, Am Markt Zeile 3-5, D-66125, Saarbrücken, Germany.
  • Kickelbick G; Institute of Inorganic Solid State Chemistry, Saarland University, Campus Dudweiler, Am Markt Zeile 3-5, D-66125, Saarbrücken, Germany.
  • Bals R; Department of Internal Medicine V, Pneumology, Allergology and Respiratory Critical Care Medicine, Saarland University Faculty of Medicine, Kirrberger Str. 100, D-66421, Homburg/Saar, Germany.
  • Nguyen J; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, 303 Kapoor Hall, SUNY Buffalo, NY, 14214, USA.
  • Dinh QT; Department of Experimental Pneumology and Allergology, Saarland University Faculty of Medicine, Kirrberger Str. 100, D-66421, Homburg/Saar, Germany.
Small ; 13(10)2017 03.
Article en En | MEDLINE | ID: mdl-28009478
Nanotechnology is showing promise in many medical applications such as drug delivery and hyperthermia. Nanoparticles administered to the respiratory tract cause local reactions and cross the blood-air barrier, thereby providing a means for easy systemic administration but also a potential source of toxicity. Little is known about how these effects are influenced by preexisting airway diseases such as asthma. Here, BALB/c mice are treated according to the ovalbumin (OVA) asthma protocol to promote allergic airway inflammation. Dispersions of polyethylene-glycol-coated (PEGylated) and citrate/tannic-acid-coated (citrated) 5 nm gold nanoparticles are applied intranasally to asthma and control groups, and (i) airway resistance and (ii) local tissue effects are measured as primary endpoints. Further, nanoparticle uptake into extrapulmonary organs is quantified by inductively coupled plasma mass spectrometry. The asthmatic precondition increases nanoparticle uptake. Moreover, systemic uptake is higher for PEGylated gold nanoparticles compared to citrated nanoparticles. Nanoparticles inhibit both inflammatory infiltrates and airway hyperreactivity, especially citrated gold nanoparticles. Although the antiinflammatory effects of gold nanoparticles might be of therapeutic benefit, systemic uptake and consequent adverse effects must be considered when designing and testing nanoparticle-based asthma therapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Nanotecnología / Nanopartículas del Metal / Oro Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Nanotecnología / Nanopartículas del Metal / Oro Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania