Mechanism of Degradation of an &#945;-Keto-Epoxide, a Model for the Warhead for Various Proteasome Inhibitor Anticancer Agents.

Phizackerley, Kirsten M; Jumaa, Mouhannad; Lopalco, Antonio; Wolfe, Bradley H; Ablan, Christopher D; Stella, Valentino J

Mechanism of Degradation of an α-Keto-Epoxide, a Model for the Warhead for Various Proteasome Inhibitor Anticancer Agents.

Phizackerley, Kirsten M; Jumaa, Mouhannad; Lopalco, Antonio; Wolfe, Bradley H; Ablan, Christopher D; Stella, Valentino J.

Afiliación

Phizackerley KM; Onyx, a Subsidiary of Amgen, South San Francisco, California 94901.
Jumaa M; Onyx, a Subsidiary of Amgen, South San Francisco, California 94901.
Lopalco A; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas 66047.
Wolfe BH; Onyx, a Subsidiary of Amgen, South San Francisco, California 94901.
Ablan CD; Onyx, a Subsidiary of Amgen, South San Francisco, California 94901.
Stella VJ; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas 66047. Electronic address: stella@ku.edu.

J Pharm Sci ; 106(4): 1051-1061, 2017 04.

Article en En | MEDLINE | ID: mdl-28007565

Asunto(s)

Antineoplásicos/química; Compuestos Epoxi/química; Modelos Químicos; Inhibidores de Proteasoma/química; Antineoplásicos/metabolismo; Compuestos Epoxi/metabolismo; Soluciones Farmacéuticas/química; Soluciones Farmacéuticas/metabolismo; Inhibidores de Proteasoma/metabolismo

Palabras clave

cancer chemotherapy; chemical stability; degradation products; hydrolysis; kinetics; stability; stabilization

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Epoxi / Inhibidores de Proteasoma / Modelos Químicos / Antineoplásicos Idioma: En Revista: J Pharm Sci Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos

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