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Patients with dental calculus have increased saliva and gingival crevicular fluid fetuin-A levels but no association with fetuin-A polymorphisms.
Dogan, Gülnihal Emrem; Demir, Turgut; Laloglu, Esra; Saglam, Ebru; Aksoy, Hülya; Yildirim, Abdulkadir; Akçay, Fatih.
Afiliación
  • Dogan GE; Private practice, Erzurum, Turkey.
  • Demir T; University of Ataturk, Faculty of Dentistry, Department of Periodontology, Erzurum, Turkey.
  • Laloglu E; University of Ataturk, Faculty of Medicine,Department of Biochemistry, Erzurum, Turkey.
  • Saglam E; University of Ataturk, Faculty of Dentistry, Department of Periodontology, Erzurum, Turkey.
  • Aksoy H; University of Ataturk, Faculty of Medicine,Department of Biochemistry, Erzurum, Turkey.
  • Yildirim A; Private practice, Erzurum, Turkey.
  • Akçay F; Private practice, Erzurum, Turkey.
Braz Oral Res ; 30(1): e129, 2016 Dec 22.
Article en En | MEDLINE | ID: mdl-28001239
Fetuin-A is a potent inhibitor of calcium-phosphate precipitation and of the calcification process, therefore it can also be related with dental calculus. Thus, we aimed to investigate a possible relationship between fetuin-A gene polymorphism and the presence of dental calculus. A possible relationship between serum, saliva and gingival crevicular fluid (GCF) levels of fetuin-A was also investigated. Fetuin-A c.742C > T and c.766C > G polymorphisms were investigated in 103 patients with or without dental calculus. Additionally, serum, saliva and GCF fetuin-A levels of patients were compared according to dental calculus presence. A significant difference was not observed in the distribution of the fetuin-A c.742C > T and c.766C > G polymorphisms between patients with or without dental calculus. Saliva and GCF fetuin-A concentrations of patients with dental calculus were statistically higher than those without dental calculus (P=0.001, P=0.036 respectively). According to our results, fetuin-A c.742C > T and c.766C > G polymorphisms were not associated with presence of dental calculus. However, higher GCF and saliva fetuin-A levels were detected in patients with dental calculus than in patients without dental calculus, which may result from an adaptive mechanism to inhibit mineral precipitation and eventually calculus formation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Saliva / Cálculos Dentales / Líquido del Surco Gingival / Alfa-2-Glicoproteína-HS Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Braz Oral Res Asunto de la revista: ODONTOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Saliva / Cálculos Dentales / Líquido del Surco Gingival / Alfa-2-Glicoproteína-HS Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Braz Oral Res Asunto de la revista: ODONTOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Brasil