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Oxidant Status following Cardiac Surgery with Phosphorylcholine-Coated Extracorporeal Circulation Systems.
Hatemi, Ali Can; Çeviker, Kadir; Tongut, Aybala; Özgöl, Ilhan; Mert, Murat; Kaya, Aysem.
Afiliación
  • Hatemi AC; Department of Cardiovascular Surgery, Institute of Cardiology, Istanbul University, Istanbul, Turkey.
  • Çeviker K; Department of Cardiovascular Surgery, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
  • Tongut A; Pediatric Cardiac Surgery Clinic, Kartal Kosuyolu YIEAH, Istanbul, Turkey.
  • Özgöl I; Department of Cardiovascular Surgery, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
  • Mert M; Department of Cardiovascular Surgery, Institute of Cardiology, Istanbul University, Istanbul, Turkey.
  • Kaya A; Division of Biochemistry, Institute of Cardiology, Istanbul University, Istanbul, Turkey.
Oxid Med Cell Longev ; 2016: 3932092, 2016.
Article en En | MEDLINE | ID: mdl-27994711
Introduction. Extracorporeal circulation (ECC) related systemic oxidative stress is a well-known entity but the underlying mechanisms are not clearly described. Our aim was to investigate the relation between the oxidative stress indices, inflammatory markers, and phosphorylcholine-coated (PCC) ECC systems. Patients and Methods. Thirty-two consecutive coronary artery bypass grafting (CABG) cases were randomly assigned to Group I (PCC, n = 18) and Group II (noncoated, n = 14) ECC circuits. Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Tumor Necrosis Factor-α (TNF-α), Interleukin-1ß (IL-ß), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10), and Procalcitonin (PCT) levels were measured at 5 different time points. The association between the oxidative indices levels and PCC system used was analyzed. Results. In Group I TOS and TAS statuses were increased at T1, T2, T3, and T4, while IL-10 and TNF-α levels accompanied those raises only at T2 (Group I-Group II, 4.73 ± 2.04 versus 2.79 ± 0.63, p = 0.002, and 30.56 ± 8.11 versus 23.97 ± 7.8, p = 0.031, resp.). In contrast, mean TAS and TOS levels were similar to baseline at all time points in Group II but IL-6 and IL-8 levels were increased at T2 (Group I-Group II, 16.84 ± 5.63 versus 44.81 ± 17.0, p = 0.001, and 38.88 ± 9.8 versus 46.14 ± 9.25, p = 0.038, resp.). Conclusion. Even coated ECC systems are still incapable of attenuating the inflammatory response to cardiopulmonary bypass (CPB).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosforilcolina / Puente de Arteria Coronaria / Oxidantes / Circulación Extracorporea Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosforilcolina / Puente de Arteria Coronaria / Oxidantes / Circulación Extracorporea Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos