Your browser doesn't support javascript.
loading
Optical and Magnetic Resonance Imaging Using Fluorous Colloidal Nanoparticles.
Wallat, Jaqueline D; Czapar, Anna E; Wang, Charlie; Wen, Amy M; Wek, Kristen S; Yu, Xin; Steinmetz, Nicole F; Pokorski, Jonathan K.
Afiliación
  • Wallat JD; Department of Macromolecular Science and Engineering, Case Western Reserve University, Case School of Engineering , Cleveland, Ohio 44106, United States.
  • Czapar AE; Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, Ohio 44106, United States.
  • Wang C; Department of Biomedical Engineering, Case Western Reserve University School of Medicine and Case School of Engineering , Cleveland, Ohio 44106, United States.
  • Wen AM; Department of Biomedical Engineering, Case Western Reserve University School of Medicine and Case School of Engineering , Cleveland, Ohio 44106, United States.
  • Wek KS; Department of Macromolecular Science and Engineering, Case Western Reserve University, Case School of Engineering , Cleveland, Ohio 44106, United States.
  • Yu X; Department of Biomedical Engineering, Case Western Reserve University School of Medicine and Case School of Engineering , Cleveland, Ohio 44106, United States.
  • Steinmetz NF; Department of Macromolecular Science and Engineering, Case Western Reserve University, Case School of Engineering , Cleveland, Ohio 44106, United States.
  • Pokorski JK; Department of Biomedical Engineering, Case Western Reserve University School of Medicine and Case School of Engineering , Cleveland, Ohio 44106, United States.
Biomacromolecules ; 18(1): 103-112, 2017 01 09.
Article en En | MEDLINE | ID: mdl-27992176
Improved imaging of cancerous tissue has the potential to aid prognosis and improve patient outcome through longitudinal imaging of treatment response and disease progression. While nuclear imaging has made headway in cancer imaging, fluorinated tracers that enable magnetic resonance imaging (19F MRI) hold promise, particularly for repeated imaging sessions because nonionizing radiation is used. Fluorine MRI detects molecular signatures by imaging a fluorinated tracer and takes advantage of the spatial and anatomical resolution afforded by MRI. This manuscript describes a fluorous polymeric nanoparticle that is capable of 19F MR imaging and fluorescent tracking for in vitro and in vivo monitoring of immune cells and cancerous tissue. The fluorous particle is derived from low-molecular-weight amphiphilic copolymers that self-assemble into micelles with a hydrodynamic diameter of 260 nm. The polymer is MR-active at concentrations as low as 2.1 mM in phantom imaging studies. The fluorinated particle demonstrated rapid uptake into immune cells for potential cell-tracking or delineation of the tumor microenvironment and showed negligible toxicity. Systemic administration indicates significant uptake into two tumor types, triple-negative breast cancer and ovarian cancer, with little accumulation in off-target tissue. These results indicate a robust platform imaging agent capable of immune cell tracking and systemic disease monitoring with exceptional uptake of the nanoparticle in multiple cancer models.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Polímeros / Nanopartículas / Imagen Óptica / Neoplasias de la Mama Triple Negativas / Imagen por Resonancia Magnética con Fluor-19 / Macrófagos Límite: Female / Humans Idioma: En Revista: Biomacromolecules Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Polímeros / Nanopartículas / Imagen Óptica / Neoplasias de la Mama Triple Negativas / Imagen por Resonancia Magnética con Fluor-19 / Macrófagos Límite: Female / Humans Idioma: En Revista: Biomacromolecules Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos