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Characterizing human cytomegalovirus reinfection in congenitally infected infants: an evolutionary perspective.
Pokalyuk, Cornelia; Renzette, Nicholas; Irwin, Kristen K; Pfeifer, Susanne P; Gibson, Laura; Britt, William J; Yamamoto, Aparecida Y; Mussi-Pinhata, Marisa M; Kowalik, Timothy F; Jensen, Jeffrey D.
Afiliación
  • Pokalyuk C; Institute for Mathematics, Goethe Universität Frankfurt, Frankfurt am Main, Germany.
  • Renzette N; Faculty for Mathematics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
  • Irwin KK; School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Pfeifer SP; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
  • Gibson L; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
  • Britt WJ; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
  • Yamamoto AY; School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Mussi-Pinhata MM; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
  • Kowalik TF; School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Jensen JD; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
Mol Ecol ; 26(7): 1980-1990, 2017 Apr.
Article en En | MEDLINE | ID: mdl-27988973
Given the strong selective pressures often faced by populations when colonizing a novel habitat, the level of variation present on which selection may act is an important indicator of adaptive potential. While often discussed in an ecological context, this notion is also highly relevant in our clinical understanding of viral infection, in which the novel habitat is a new host. Thus, quantifying the factors determining levels of variation is of considerable importance for the design of improved treatment strategies. Here, we focus on such a quantification of human cytomegalovirus (HCMV) - a virus which can be transmitted across the placenta, resulting in foetal infection that can potentially cause severe disease in multiple organs. Recent studies using genomewide sequencing data have demonstrated that viral populations in some congenitally infected infants diverge rapidly over time and between tissue compartments within individuals, while in other infants, the populations remain highly stable. Here, we investigate the underlying causes of these extreme differences in observed intrahost levels of variation by estimating the underlying demographic histories of infection. Importantly, reinfection (i.e. population admixture) appears to be an important, and previously unappreciated, player. We highlight illustrative examples likely to represent a single-population transmission from a mother during pregnancy and multiple-population transmissions during pregnancy and after birth.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Infecciones por Citomegalovirus / Evolución Molecular / Citomegalovirus / Genética de Población Tipo de estudio: Prognostic_studies Límite: Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: Mol Ecol Asunto de la revista: BIOLOGIA MOLECULAR / SAUDE AMBIENTAL Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Infecciones por Citomegalovirus / Evolución Molecular / Citomegalovirus / Genética de Población Tipo de estudio: Prognostic_studies Límite: Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: Mol Ecol Asunto de la revista: BIOLOGIA MOLECULAR / SAUDE AMBIENTAL Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido