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Phenylephrine increases near-infrared spectroscopy determined muscle oxygenation in men.
Sørensen, H; Thomsen, J H; Meyer, A S P; Terzic, D; Hilsted, L; Kjærgaard, J; Goetze, J P; Barbosa, T C; Secher, N H.
Afiliación
  • Sørensen H; Department of Anesthesia, The Copenhagen Muscle Research Centre, University of Copenhagen, Rigshospitalet 2043, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark. hs770@hotmail.com.
  • Thomsen JH; Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Meyer ASP; Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Terzic D; Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Hilsted L; Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Kjærgaard J; Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Goetze JP; Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Barbosa TC; Laboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Brazil.
  • Secher NH; Department of Anesthesia, The Copenhagen Muscle Research Centre, University of Copenhagen, Rigshospitalet 2043, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark.
J Clin Monit Comput ; 31(6): 1159-1166, 2017 Dec.
Article en En | MEDLINE | ID: mdl-27987104
Phenylephrine increases mean arterial pressure (MAP) by enhanced total peripheral resistance (TPR) but near-infrared spectroscopy (NIRS) determined muscle oxygenation (SmO2) increases. We addressed that apparent paradox during supine rest and head-up tilt (HUT). Variables were determined ± phenylephrine in males during supine rest (n = 17) and 40° HUT (n = 7). MAP, stroke volume (SV), heart rate (HR), and TPR were derived by Modelflow® and NIRS determined biceps SmO2 and (tibial) bone oxygenation (StibialO2). For ten subjects, cardiac filling and the diameter of the inferior caval vein (ICV collapsibility index: ((ICVexpiration - ICVinspiration)/ICVexpiration) × 100) were assessed by ultrasound. Pancreatic polypeptide (PP) and atrial natriuretic peptide (proANP) in plasma were determined by immunoassay. Brachial artery blood flow was assessed by ultrasound and skin oxygenation (SskinO2) monitored by white light spectroscopy. Phenylephrine increased MAP by 34% and TPR (62%; P < 0.001) during supine rest. The ICV collapsibility index decreased (24%; P < 0.001) indicating augmented cardiac preload although volume of the left atrium and ventricle did not change. SV increased (18%; P < 0.001) as HR decreased (24%; P < 0.001). ProANP increased by 9% (P = 0.002) with unaffected PP. Brachial artery blood flow tended to decrease while SskinO2 together with StibialO2 decreased by 11% (P = 0.026) and 20% (P < 0.001), respectively. Conversely, phenylephrine increased SmO2 (9%) and restored the HUT elicited decrease in SmO2 (by 19%) along with SV (P = 0.02). Phenylephrine reduces skin and bone oxygenation and tends to reduce arm blood flow, suggesting that the increase in SmO2 reflects veno-constriction with consequent centralization of the blood volume.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Consumo de Oxígeno / Fenilefrina / Piel / Tibia / Músculo Esquelético / Espectroscopía Infrarroja Corta Tipo de estudio: Prognostic_studies Límite: Adult / Humans / Male Idioma: En Revista: J Clin Monit Comput Asunto de la revista: INFORMATICA MEDICA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Consumo de Oxígeno / Fenilefrina / Piel / Tibia / Músculo Esquelético / Espectroscopía Infrarroja Corta Tipo de estudio: Prognostic_studies Límite: Adult / Humans / Male Idioma: En Revista: J Clin Monit Comput Asunto de la revista: INFORMATICA MEDICA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Países Bajos