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Genomic characterization of pediatric B-lymphoblastic lymphoma and B-lymphoblastic leukemia using formalin-fixed tissues.
Meyer, Julia A; Zhou, Delu; Mason, Clinton C; Downie, Jonathan M; Rodic, Vladimir; Abromowitch, Minnie; Wistinghausen, Birte; Termuhlen, Amanda M; Angiolillo, Anne L; Perkins, Sherrie L; Lones, Mark A; Barnette, Phillip; Schiffman, Joshua D; Miles, Rodney R.
Afiliación
  • Meyer JA; Department of Oncological Sciences, University of Utah, Salt Lake City, Utah.
  • Zhou D; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
  • Mason CC; Department of Pathology, University of Utah, Salt Lake City, Utah.
  • Downie JM; Department of Pediatrics, University of Utah, Salt Lake City, Utah.
  • Rodic V; Department of Human Genetics, University of Utah, Salt Lake City, Utah.
  • Abromowitch M; Department of Pathology, University of Utah, Salt Lake City, Utah.
  • Wistinghausen B; Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska.
  • Termuhlen AM; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Angiolillo AL; Department of Pediatrics, Keck School of Medicine at the University of Southern California, Children's Hospital Los Angeles, Los Angeles, California.
  • Perkins SL; Division of Oncology, Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, District of Columbia.
  • Lones MA; Department of Pathology, University of Utah, Salt Lake City, Utah.
  • Barnette P; ARUP Institute for Experimental Pathology, Salt Lake City, Utah.
  • Schiffman JD; Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California.
  • Miles RR; Department of Pediatrics, University of Utah, Salt Lake City, Utah.
Pediatr Blood Cancer ; 64(7)2017 Jul.
Article en En | MEDLINE | ID: mdl-27957801
BACKGROUND: Recurrent genomic changes in B-lymphoblastic leukemia (B-ALL) identified by genome-wide single-nucleotide polymorphism (SNP) microarray analysis provide important prognostic information, but gene copy number analysis of its rare lymphoma counterpart, B-lymphoblastic lymphoma (B-LBL), is limited by the low incidence and lack of fresh tissue for genomic testing. PROCEDURE: We used molecular inversion probe (MIP) technology to analyze and compare copy number alterations (CNAs) in archival formalin-fixed paraffin-embedded pediatric B-LBL (n = 23) and B-ALL (n = 55). RESULTS: Similar to B-ALL, CDKN2A/B deletions were the most common alteration identified in 6/23 (26%) B-LBL cases. Eleven of 23 (48%) B-LBL patients were hyperdiploid, but none showed triple trisomies (chromosomes 4, 10, and 17) characteristic of B-ALL. IKZF1 and PAX5 deletions were observed in 13 and 17% of B-LBL, respectively, which was similar to the reported frequency in B-ALL. Immunoglobulin light chain lambda (IGL) locus deletions consistent with normal light chain rearrangement were observed in 5/23 (22%) B-LBL cases, compared with only 1% in B-ALL samples. None of the B-LBL cases showed abnormal, isolated VPREB1 deletion adjacent to IGL locus, which we identified in 25% of B-ALL. CONCLUSIONS: Our study demonstrates that the copy number profile of B-LBL is distinct from B-ALL, suggesting possible differences in pathogenesis between these closely related diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B Tipo de estudio: Prognostic_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B Tipo de estudio: Prognostic_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos