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Breaking down the gut microbiome composition in multiple sclerosis.
Budhram, Adrian; Parvathy, Seema; Kremenchutzky, Marcelo; Silverman, Michael.
Afiliación
  • Budhram A; Department of Clinical Neurological Sciences, Division of Neurology, University Hospital, London, ON, Canada.
  • Parvathy S; Division of Infectious Diseases, St. Joseph's Health Care, London, ON, Canada.
  • Kremenchutzky M; Department of Clinical Neurological Sciences, Division of Neurology, University Hospital, London, ON, Canada.
  • Silverman M; Division of Infectious Diseases, St. Joseph's Health Care, London, ON, Canada.
Mult Scler ; 23(5): 628-636, 2017 Apr.
Article en En | MEDLINE | ID: mdl-27956557
BACKGROUND: The gut microbiome, which consists of a highly diverse ecologic community of micro-organisms, has increasingly been studied regarding its role in multiple sclerosis (MS) immunopathogenesis. This review critically examines the literature investigating the gut microbiome in MS. METHODS: A comprehensive search was performed of PubMed databases and ECTRIMS meeting abstracts for literature relating to the gut microbiome in MS. Controlled studies examining the gut microbiome in patients with MS were included for review. RESULTS: Identified studies were predominantly case-control in their design and consistently found differences in the gut microbiome of MS patients compared to controls. We examine plausible mechanistic links between these differences and MS immunopathogenesis, and discuss the therapeutic implications of these findings. CONCLUSIONS: Review of the available literature reveals potential immunopathogenic links between the gut microbiome and MS, identifies avenues for therapeutic advancement, and emphasizes the need for further systematic study in this emerging field.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tracto Gastrointestinal / Microbiota / Microbioma Gastrointestinal / Esclerosis Múltiple Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tracto Gastrointestinal / Microbiota / Microbioma Gastrointestinal / Esclerosis Múltiple Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido