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Methyltransferase-Directed Labeling of Biomolecules and its Applications.
Deen, Jochem; Vranken, Charlotte; Leen, Volker; Neely, Robert K; Janssen, Kris P F; Hofkens, Johan.
Afiliación
  • Deen J; Laboratory of Nanoscale Biology, School of Engineering, EPFL, STI IBI-STI LBEN BM 5134 (Bâtiment BM), Station 17, CH-1015, Lausanne, Switzerland.
  • Vranken C; Laboratory of Photochemistry and Spectroscopy, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001, Heverlee, Belgium.
  • Leen V; Laboratory of Photochemistry and Spectroscopy, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001, Heverlee, Belgium.
  • Neely RK; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
  • Janssen KPF; Laboratory of Photochemistry and Spectroscopy, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001, Heverlee, Belgium.
  • Hofkens J; Laboratory of Photochemistry and Spectroscopy, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001, Heverlee, Belgium.
Angew Chem Int Ed Engl ; 56(19): 5182-5200, 2017 05 02.
Article en En | MEDLINE | ID: mdl-27943567
Methyltransferases (MTases) form a large family of enzymes that methylate a diverse set of targets, ranging from the three major biopolymers to small molecules. Most of these MTases use the cofactor S-adenosyl-l-Methionine (AdoMet) as a methyl source. In recent years, there have been significant efforts toward the development of AdoMet analogues with the aim of transferring moieties other than simple methyl groups. Two major classes of AdoMet analogues currently exist: doubly-activated molecules and aziridine based molecules, each of which employs a different approach to achieve transalkylation rather than transmethylation. In this review, we discuss the various strategies for labelling and functionalizing biomolecules using AdoMet-dependent MTases and AdoMet analogues. We cover the synthetic routes to AdoMet analogues, their stability in biological environments and their application in transalkylation reactions. Finally, some perspectives are presented for the potential use of AdoMet analogues in biology research, (epi)genetics and nanotechnology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biopolímeros / Bibliotecas de Moléculas Pequeñas / Metiltransferasas Idioma: En Revista: Angew Chem Int Ed Engl Año: 2017 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biopolímeros / Bibliotecas de Moléculas Pequeñas / Metiltransferasas Idioma: En Revista: Angew Chem Int Ed Engl Año: 2017 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Alemania