Your browser doesn't support javascript.
loading
Clinical Profile and Changes of Serum Lipid Levels in Epileptic Patients after Cerebral Infarction.
Ikeda, Ken; Sawada, Masahiro; Morioka, Harumi; Kyuzen, Maya; Ebina, Junya; Nagasawa, Junpei; Yanagihashi, Masaru; Miura, Ken; Ishikawa, Yuichi; Hirayama, Takehisa; Takazawa, Takanori; Kano, Osamu; Kawabe, Kiyokazu; Iwasaki, Yasuo.
Afiliación
  • Ikeda K; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan. Electronic address: keni@med.toho-u.ac.jp.
  • Sawada M; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
  • Morioka H; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
  • Kyuzen M; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
  • Ebina J; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
  • Nagasawa J; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
  • Yanagihashi M; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
  • Miura K; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
  • Ishikawa Y; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
  • Hirayama T; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
  • Takazawa T; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
  • Kano O; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
  • Kawabe K; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
  • Iwasaki Y; Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
J Stroke Cerebrovasc Dis ; 26(3): 644-649, 2017 Mar.
Article en En | MEDLINE | ID: mdl-27939141
BACKGROUND: Antiepileptic drugs (AEDs) may increase development of dyslipidemia and cerebrovascular disease (CVD). We examined the clinical profile and changes of serum lipid levels after AED monotherapy in patients with poststroke epilepsy (PSE) after cerebral infarction (CI). SUBJECTS AND METHODS: Medical records were reviewed in consecutive 2144 CI patients. Monotherapy of valproate, carbamazepine (CBZ), phenytoin (PHT), zonisamide, levetiracetam, or lamotrigine was performed in PSE patients. Serum lipid levels were measured before and at 3 months after AED treatment. RESULTS: The prevalence of PSE was 7.0% in CI patients. The TOAST etiology disclosed large-artery atherosclerosis in 68 patients (45%), cardioembolism in 63 patients (42%), and undetermined cause in 19 patients (13%). CVD risk profile showed obesity of 18 patients (12%), current smoker of 30 patients (20%), hypertension of 75 patients (50%), diabetes mellitus of 32 patients (21%), dyslipidemia of 15 patients (10%), and atrial fibrillation of 63 patients (42%). CBZ or PHT administration increased serum total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) levels significantly compared to baseline and AED-untreated controls. Those levels were not increased significantly in other AED and control groups. Serum high-density lipoprotein-cholesterol and triglyceride levels did not differ statistically in all groups. CONCLUSIONS: The prevalence of post-CI epilepsy was 7.0%. The pathogenesis contributed to atherothrombosis and cardioembolism. CBZ or PHT administration increased serum TC and LDL-C significantly. Thus, we should pay more attention to serum lipid levels in patients receiving cytochrome P450 (CYP)-induced AEDs, and might considerer switching to non-CYP-induced AEDs in patients with unfavorable serum lipid changes.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infarto Cerebral / Epilepsia / Lípidos Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Stroke Cerebrovasc Dis Asunto de la revista: ANGIOLOGIA / CEREBRO Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infarto Cerebral / Epilepsia / Lípidos Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Stroke Cerebrovasc Dis Asunto de la revista: ANGIOLOGIA / CEREBRO Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos