NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus.

Demitrack, Elise S; Gifford, Gail B; Keeley, Theresa M; Horita, Nobukatsu; Todisco, Andrea; Turgeon, D Kim; Siebel, Christian W; Samuelson, Linda C

Demitrack, Elise S; Gifford, Gail B; Keeley, Theresa M; Horita, Nobukatsu; Todisco, Andrea; Turgeon, D Kim; Siebel, Christian W; Samuelson, Linda C.

Afiliación

Demitrack ES; Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, Michigan.
Gifford GB; Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, Michigan.
Keeley TM; Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, Michigan.
Horita N; Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, Michigan.
Todisco A; Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan; and.
Turgeon DK; Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan; and.
Siebel CW; Department of Discovery Oncology, Genentech, Incorporated, San Francisco, California.
Samuelson LC; Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, Michigan; lcsam@umich.edu.

Am J Physiol Gastrointest Liver Physiol ; 312(2): G133-G144, 2017 Feb 01.

Article en En | MEDLINE | ID: mdl-27932500

Asunto(s)

Proliferación Celular/fisiología; Células Epiteliales/fisiología; Receptor Notch1/metabolismo; Receptor Notch2/metabolismo; Estómago/fisiología; Animales; Femenino; Mucosa Gástrica/citología; Genes Reporteros; Humanos; Masculino; Ratones; Organoides/citología; Organoides/fisiología; Receptor Notch1/genética; Receptor Notch2/genética; Transducción de Señal/fisiología; Células Madre; Tamoxifeno/farmacología

Palabras clave

SOX2; cellular differentiation; gastric organoids; gastric stem cells; spasmolytic polypeptide expressing metaplasia (SPEM)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estómago / Proliferación Celular / Células Epiteliales / Receptor Notch1 / Receptor Notch2 Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Am J Physiol Gastrointest Liver Physiol Asunto de la revista: FISIOLOGIA / GASTROENTEROLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos

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