Intracellular allosteric antagonism of the CCR9 receptor.

Oswald, Christine; Rappas, Mathieu; Kean, James; Doré, Andrew S; Errey, James C; Bennett, Kirstie; Deflorian, Francesca; Christopher, John A; Jazayeri, Ali; Mason, Jonathan S; Congreve, Miles; Cooke, Robert M; Marshall, Fiona H

Oswald, Christine; Rappas, Mathieu; Kean, James; Doré, Andrew S; Errey, James C; Bennett, Kirstie; Deflorian, Francesca; Christopher, John A; Jazayeri, Ali; Mason, Jonathan S; Congreve, Miles; Cooke, Robert M; Marshall, Fiona H.

Afiliación

Oswald C; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Rappas M; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Kean J; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Doré AS; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Errey JC; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Bennett K; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Deflorian F; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Christopher JA; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Jazayeri A; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Mason JS; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Congreve M; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Cooke RM; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Marshall FH; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.

Nature ; 540(7633): 462-465, 2016 12 15.

Article en En | MEDLINE | ID: mdl-27926729

Asunto(s)

Receptores CCR/antagonistas & inhibidores; Receptores CCR/química; Sulfonamidas/química; Sulfonamidas/farmacología; Regulación Alostérica/efectos de los fármacos; Sitio Alostérico/efectos de los fármacos; Sitio Alostérico/genética; Secuencia Conservada; Cristalografía por Rayos X; Citoplasma/metabolismo; Diseño de Fármacos; Proteínas de Unión al GTP Heterotriméricas/antagonistas & inhibidores; Proteínas de Unión al GTP Heterotriméricas/metabolismo; Humanos; Ligandos; Modelos Moleculares; Mutagénesis; Receptores CCR/genética; Receptores CCR5/química; Receptores CXCR4/química

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfonamidas / Receptores CCR Límite: Humans Idioma: En Revista: Nature Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido

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