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Serum uric acid is independently and linearly associated with risk of nonalcoholic fatty liver disease in obese Chinese adults.
Liu, Chang-Qin; He, Chun-Mei; Chen, Ning; Wang, Dongmei; Shi, Xiulin; Liu, Yongwen; Zeng, Xin; Yan, Bing; Liu, Suhuan; Yang, Shuyu; Li, Xiaoying; Li, Xuejun; Li, Zhibin.
Afiliación
  • Liu CQ; Department of Endocrinology and Diabetes, the First Affiliated Hospital, Xiamen University, Xiamen, China.
  • He CM; Xiamen Diabetes Institute, Xiamen, China.
  • Chen N; Department of Endocrinology and Diabetes, the First Affiliated Hospital, Xiamen University, Xiamen, China.
  • Wang D; School of Public Health, Xiamen University, Xiamen, China.
  • Shi X; Department of Endocrinology and Diabetes, the First Affiliated Hospital, Xiamen University, Xiamen, China.
  • Liu Y; Department of Endocrinology and Diabetes, the First Affiliated Hospital, Xiamen University, Xiamen, China.
  • Zeng X; Xiamen Diabetes Institute, Xiamen, China.
  • Yan B; Xiamen Diabetes Institute, Xiamen, China.
  • Liu S; Xiamen Diabetes Institute, Xiamen, China.
  • Yang S; Department of Endocrinology and Diabetes, the First Affiliated Hospital, Xiamen University, Xiamen, China.
  • Li X; Xiamen Diabetes Institute, Xiamen, China.
  • Li X; Department of Endocrinology and Diabetes, the First Affiliated Hospital, Xiamen University, Xiamen, China.
  • Li Z; Xiamen Diabetes Institute, Xiamen, China.
Sci Rep ; 6: 38605, 2016 12 07.
Article en En | MEDLINE | ID: mdl-27924915
The present study aimed to explore the independent association and potential pathways between serum uric acid (SUA) and nonalcoholic fatty liver disease (NAFLD). 1365 community-living obese Chinese adults who received hepatic ultrasonography scanning were included. The prevalence rates of NAFLD were 71.5% for men and 53.8% for women. Compared with controls, NAFLD subjects showed significantly increased SUA levels (333.3 ± 84.9 v.s. 383.4 ± 93.7 µmol/L) and prevalence rate of hyperuricemia (HUA) (25.7% v.s. 47.3%, p < 0.001). After adjustment for insulin resistance (IR), components of metabolic syndrome (MetS) and other potential confounders, elevated SUA is independently associated with increased risk of NAFLD, with the adjusted OR of 1.528-2.031 (p < 0.001). By using multivariable fractional polynomial (MFP) modeling, the best FP transformation model shows that SUA was independently and linearly associated with risk of NAFLD. The one-pathway model by using structural equation modeling (SEM) about the relationships among SUA, IR, components of metabolic syndrome and NAFLD fits well (χ2 = 57.367, p < 0.001; CFI = 0.998; TLI = 0.992; and RMSEA = 0.048) and shows SUA might increase the risk of NAFLD directly besides of the indirect effects through increasing fasting insulin, blood pressure, triglyceride and decreasing HDL-C levels. Our results imply that elevated SUA may play an important role in NAFLD pathogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Susceptibilidad a Enfermedades / Enfermedad del Hígado Graso no Alcohólico / Obesidad Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Susceptibilidad a Enfermedades / Enfermedad del Hígado Graso no Alcohólico / Obesidad Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido