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An Essential Role of Maspin in Embryogenesis and Tumor Suppression.
Dzinic, Sijana H; Bernardo, M Margarida; Li, Xiaohua; Fernandez-Valdivia, Rodrigo; Ho, Ye-Shih; Mi, Qing-Sheng; Bandyopadhyay, Sudeshna; Lonardo, Fulvio; Vranic, Semir; Oliveira, Daniel S M; Bonfil, R Daniel; Dyson, Gregory; Chen, Kang; Omerovic, Almasa; Sheng, Xiujie; Han, Xiang; Wu, Dinghong; Bi, Xinling; Cabaravdic, Dzenana; Jakupovic, Una; Wahba, Marian; Pang, Aaron; Harajli, Deanna; Sakr, Wael A; Sheng, Shijie.
Afiliación
  • Dzinic SH; Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
  • Bernardo MM; Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.
  • Li X; Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
  • Fernandez-Valdivia R; Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.
  • Ho YS; Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
  • Mi QS; Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.
  • Bandyopadhyay S; Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
  • Lonardo F; Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.
  • Vranic S; Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, Michigan.
  • Oliveira DS; Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.
  • Bonfil RD; Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan.
  • Dyson G; Department of Dermatology, Henry Ford Health Systems, Detroit, Michigan.
  • Chen K; Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
  • Omerovic A; Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.
  • Sheng X; Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
  • Han X; Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.
  • Wu D; Division of Experimental Pathology, Department of Pathology, University Clinical Center, Sarajevo, Bosnia and Herzegovina.
  • Bi X; Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
  • Cabaravdic D; Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.
  • Jakupovic U; Department of Urology, Wayne State University School of Medicine, Detroit, Michigan.
  • Wahba M; Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
  • Pang A; Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.
  • Harajli D; Department of Urology, Wayne State University School of Medicine, Detroit, Michigan.
  • Sakr WA; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.
  • Sheng S; Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.
Cancer Res ; 77(4): 886-896, 2017 02 15.
Article en En | MEDLINE | ID: mdl-27923833
Maspin (SerpinB5) is an epithelial-specific tumor suppressor gene product that displays context-dependent cellular functions. Maspin-deficient mouse models created to date have not definitively established maspin functions critical for cancer suppression. In this study, we generated a mouse strain in which exon 4 of the Maspin gene was deleted, confirming its essential role in development but also enabling a breeding scheme to bypass embryonic lethality. Phenotypic characterization of this viable strain established that maspin deficiency was associated with a reduction in maximum body weight and a variety of context-dependent epithelial abnormalities. Specifically, maspin-deficient mice exhibited pulmonary adenocarcinoma, myoepithelial hyperplasia of the mammary gland, hyperplasia of luminal cells of dorsolateral and anterior prostate, and atrophy of luminal cells of ventral prostate and stratum spinosum of epidermis. These cancer phenotypes were accompanied by increased inflammatory stroma. These mice also displayed the autoimmune disorder alopecia aerate. Overall, our findings defined context-specific tumor suppressor roles for maspin in a clinically relevant model to study maspin functions in cancer and other pathologies. Cancer Res; 77(4); 886-96. ©2017 AACR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serpinas / Proteínas Supresoras de Tumor / Desarrollo Embrionario Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Cancer Res Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serpinas / Proteínas Supresoras de Tumor / Desarrollo Embrionario Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Cancer Res Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos