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Thyroid Function in Human Obesity: Underlying Mechanisms.
Fontenelle, L C; Feitosa, M M; Severo, J S; Freitas, T E C; Morais, J B S; Torres-Leal, F L; Henriques, G S; do Nascimento Marreiro, D.
Afiliación
  • Fontenelle LC; Department of Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil.
  • Feitosa MM; Department of Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil.
  • Severo JS; Department of Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil.
  • Freitas TE; Department of Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil.
  • Morais JB; Department of Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil.
  • Torres-Leal FL; Department of Biophysics and Physiology, Federal University of Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina, Piauí, Brazil.
  • Henriques GS; Department of School of Nursing, Federal University of Minas Gerais, Santa Efigênia, Belo Horizonte, Minas Gerais, Brazil.
Horm Metab Res ; 48(12): 787-794, 2016 Dec.
Article en En | MEDLINE | ID: mdl-27923249
Obesity is associated with several metabolic and endocrine disorders; and changes in plasma concentrations, secretion patterns, and clearance of various hormones are observed in obese patients. In this context, recent research has shown that overweight can influence the function of the thyroid gland, usually leading to increased thyrotropin concentrations and changes in the ratio between the hormones triiodothyronine and thyroxine, though within the normal range. The etiology of these changes is still unclear; however, several mechanisms have been proposed including the adaptive process to increase energy expenditure, hyperleptinemia, changes in the activity of deiodinases, the presence of thyroid hormones resistance, chronic low-grade inflammation, and insulin resistance. Although the clinical implications have not been clarified, studies suggest that these changes in the thyroid function of obese individuals may contribute to the worsening of metabolic complications and the development of diseases in the thyroid gland.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándula Tiroides / Obesidad Límite: Humans Idioma: En Revista: Horm Metab Res Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándula Tiroides / Obesidad Límite: Humans Idioma: En Revista: Horm Metab Res Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania