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Squamous Cell Carcinoma in African Children with Xeroderma Pigmentosum: Three Case Reports.
Kaloga, Mamadou; Dioussé, Pauline; Diatta, Boubacar Ahy; Bammo, Mariama; Kourouma, Sarah; Diabate, Almamy; Gueye, Ndiaga; Dione, Haby; Diallo, Moussa; Diop, Bernard Marcel.
Afiliación
  • Kaloga M; Dermatology, University of Cocody, Abidjan, Côte d'Ivoire.
  • Dioussé P; Dermatology, Faculty of Health Sciences, University of Thies, Thies, Senegal.
  • Diatta BA; Dermatology, Hospital Aristide Le Dantec, Cheikh Anta Diop University, Dakar, Senegal.
  • Bammo M; Dermatology, Regional Hospital Thies, Thies, Senegal.
  • Kourouma S; Dermatology, University of Cocody, Abidjan, Côte d'Ivoire.
  • Diabate A; Dermatology, University Alassane Ouattara, Bouake, Côte d'Ivoire.
  • Gueye N; Dermatology, Regional Hospital Thies, Thies, Senegal.
  • Dione H; Dermatology, Faculty of Health Sciences, University of Thies, Thies, Senegal.
  • Diallo M; Dermatology, Hospital Aristide Le Dantec, Cheikh Anta Diop University, Dakar, Senegal.
  • Diop BM; Dermatology, Faculty of Health Sciences, University of Thies, Thies, Senegal.
Case Rep Dermatol ; 8(3): 311-318, 2016.
Article en En | MEDLINE | ID: mdl-27920683
INTRODUCTION: Xeroderma pigmentosum is a rare autosomal recessive genetic disease. This disease predisposes patients to early-onset skin cancers, particularly squamous cell carcinoma. Here, we report 3 pediatric cases, including 2 deaths. OBSERVATION: The subjects included 2 boys and 1 girl with skin type VI. All subjects were from consanguineous marriages, and the average age was 7.6 years. The patients all had ulcerative budding tumor lesions in the cephalic region, and the mean disease duration was 18 months. In all 3 cases, the diagnosis of xeroderma pigmentosum was made before the poikilodermal appearance of sun-exposed areas and photophobia. Neurological-type mental retardation was noted in 1 case. Histology confirmed squamous cell carcinoma in all 3 cases. The evolutions were marked by the death of 2 children (cases 1 and 3). In one case, the outcome was favorable following cancer excision and subsequent chemotherapy with adjuvant radiotherapy. CONCLUSION: Squamous cell carcinoma is a serious complication related to xeroderma pigmentosum in Sub-Saharan Africa. Prevention is based on the early diagnosis of xeroderma pigmentosum, black skin photoprotection, screening and early treatment of lesions, and genetic counseling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Screening_studies Idioma: En Revista: Case Rep Dermatol Año: 2016 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Screening_studies Idioma: En Revista: Case Rep Dermatol Año: 2016 Tipo del documento: Article Pais de publicación: Suiza