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Antihypertensive Medication Postpones the Onset of Glaucoma: Evidence From a Nationwide Study.
Horwitz, Anna; Klemp, Marc; Jeppesen, Jørgen; Tsai, James C; Torp-Pedersen, Christian; Kolko, Miriam.
Afiliación
  • Horwitz A; From the Department of Neuroscience and Pharmacology (A.H.), Center for Healthy Aging (A.H., M.K.), Department of Economics (M.K.), and Department of Drug Design and Pharmacology (M.K.), University of Copenhagen, Denmark; Department of Economics and Population Studies and Training Center, Brown Univ
  • Klemp M; From the Department of Neuroscience and Pharmacology (A.H.), Center for Healthy Aging (A.H., M.K.), Department of Economics (M.K.), and Department of Drug Design and Pharmacology (M.K.), University of Copenhagen, Denmark; Department of Economics and Population Studies and Training Center, Brown Univ
  • Jeppesen J; From the Department of Neuroscience and Pharmacology (A.H.), Center for Healthy Aging (A.H., M.K.), Department of Economics (M.K.), and Department of Drug Design and Pharmacology (M.K.), University of Copenhagen, Denmark; Department of Economics and Population Studies and Training Center, Brown Univ
  • Tsai JC; From the Department of Neuroscience and Pharmacology (A.H.), Center for Healthy Aging (A.H., M.K.), Department of Economics (M.K.), and Department of Drug Design and Pharmacology (M.K.), University of Copenhagen, Denmark; Department of Economics and Population Studies and Training Center, Brown Univ
  • Torp-Pedersen C; From the Department of Neuroscience and Pharmacology (A.H.), Center for Healthy Aging (A.H., M.K.), Department of Economics (M.K.), and Department of Drug Design and Pharmacology (M.K.), University of Copenhagen, Denmark; Department of Economics and Population Studies and Training Center, Brown Univ
  • Kolko M; From the Department of Neuroscience and Pharmacology (A.H.), Center for Healthy Aging (A.H., M.K.), Department of Economics (M.K.), and Department of Drug Design and Pharmacology (M.K.), University of Copenhagen, Denmark; Department of Economics and Population Studies and Training Center, Brown Univ
Hypertension ; 69(2): 202-210, 2017 02.
Article en En | MEDLINE | ID: mdl-27920127
The aim was to investigate the impact of antihypertensive medication on the onset of glaucoma. Data from the complete Danish population between 40 and 95 years of age were used in the period from 1996 to 2012, covering >2.6 million individuals. The National Danish Registry of Medicinal Products Statistics was used to identify all claimed prescriptions for glaucoma medication and antihypertensive drugs. We first investigated basic correlations in the data and found that patients treated with antihypertensive medication, at any time during the study period, had a significantly higher overall relative risk (RR) of glaucoma, even when controlling for age and sex (with a RR of 1.31 and P<0.0001). Furthermore, our data confirm the well-known positive association between age and glaucoma. To investigate the causal effect of antihypertensive treatment on the onset of treatment for glaucoma, we used a regression discontinuity study design. This analysis provides our main finding, namely that prescription of antihypertensive medication leads to a significant reduction in the risk of developing glaucoma. Therefore, although hypertension-as indicated by the use of antihypertensive medication-is positively correlated with glaucoma, our study indicates that antihypertensive medication itself may have a preventive effect on the development of glaucoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Glaucoma / Hipertensión / Presión Intraocular / Antihipertensivos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Humans / Infant / Middle aged / Newborn País/Región como asunto: Europa Idioma: En Revista: Hypertension Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Glaucoma / Hipertensión / Presión Intraocular / Antihipertensivos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Humans / Infant / Middle aged / Newborn País/Región como asunto: Europa Idioma: En Revista: Hypertension Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos