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Hypertension among adults exposed to drinking water arsenic in Northern Chile.
Hall, Emily M; Acevedo, Johanna; López, Francisca González; Cortés, Sandra; Ferreccio, Catterina; Smith, Allan H; Steinmaus, Craig M.
Afiliación
  • Hall EM; Texas Department of State Health Services, Austin, Texas, USA.
  • Acevedo J; Pontificia Universidad Católica de Chile, Santiago, Chile; Advanced Center for Chronic Diseases (ACCDIS), Chile.
  • López FG; Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Cortés S; Pontificia Universidad Católica de Chile, Santiago, Chile; Advanced Center for Chronic Diseases (ACCDIS), Chile.
  • Ferreccio C; Pontificia Universidad Católica de Chile, Santiago, Chile; Advanced Center for Chronic Diseases (ACCDIS), Chile.
  • Smith AH; Arsenic Health Effects Research Group, School of Public Health, University of California, Berkeley, USA.
  • Steinmaus CM; Arsenic Health Effects Research Group, School of Public Health, University of California, Berkeley, USA; Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, California, USA. Electronic address: craigs@berkeley.edu.
Environ Res ; 153: 99-105, 2017 Feb.
Article en En | MEDLINE | ID: mdl-27918984
BACKGROUND: A growing number of studies have identified an association between exposure to inorganic arsenic and hypertension. However, results have not been consistent across studies. Additional studies are warranted, given the global prevalence of both arsenic exposure and morbidity attributable to hypertension. METHODS: We analyzed data collected from October 2007-December 2010 for a population-based cancer case-control study in northern Chile. Data included lifetime individual arsenic exposure estimates and information on potential confounders for a total of 1266 subjects. Those self-reporting either a physician diagnosis of hypertension or use of an anti-hypertensive medication were classified as having hypertension (n=612). The association between hypertension and drinking water arsenic exposure was analyzed using logistic regression models. RESULTS: Compared to those in the lowest category for lifetime highest 5-year average arsenic exposure (<60µg/L), those in the middle (60-623µg/L) and upper (>623µg/L) exposure categories had adjusted hypertension ORs of 1.49 (95% CI: 1.09, 2.05) and 1.65 (95% CI: 1.18, 2.32), respectively. Similar results were observed in analyses of lifetime cumulative exposures and analyses restricted to exposures from the distant past. CONCLUSIONS: We identified evidence of increased odds of hypertension with exposure to arsenic in drinking water among study participants. Our findings add to the growing body of research supporting this association, which could have important public health implications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arsénico / Contaminantes Químicos del Agua / Agua Potable / Hipertensión Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Chile Idioma: En Revista: Environ Res Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arsénico / Contaminantes Químicos del Agua / Agua Potable / Hipertensión Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Chile Idioma: En Revista: Environ Res Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos