Gemigliptin ameliorates Western-diet-induced metabolic syndrome in mice.

Choi, Seung Hee; Leem, Jaechan; Park, Sungmi; Lee, Chong-Kee; Park, Keun-Gyu; Lee, In-Kyu

Choi, Seung Hee; Leem, Jaechan; Park, Sungmi; Lee, Chong-Kee; Park, Keun-Gyu; Lee, In-Kyu.

Afiliación

Choi SH; a Department of Biomedical Science, Graduate School, Kyungpook National University, Daegu, Republic of Korea.
Leem J; b Department of Immunology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
Park S; c Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University, Daegu, Republic of Korea.
Lee CK; b Department of Immunology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
Park KG; c Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University, Daegu, Republic of Korea.
Lee IK; d Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Can J Physiol Pharmacol ; 95(2): 129-139, 2017 Feb.

Article en En | MEDLINE | ID: mdl-27918207

Asunto(s)

Dieta Occidental/efectos adversos; Síndrome Metabólico/tratamiento farmacológico; Síndrome Metabólico/etiología; Piperidonas/farmacología; Piperidonas/uso terapéutico; Pirimidinas/farmacología; Pirimidinas/uso terapéutico; Adipocitos/patología; Animales; Hígado Graso/tratamiento farmacológico; Fibrosis/tratamiento farmacológico; Hipercolesterolemia/prevención & control; Hipertrofia/tratamiento farmacológico; Inflamación/tratamiento farmacológico; Resistencia a la Insulina; Hígado/patología; Masculino; Síndrome Metabólico/metabolismo; Síndrome Metabólico/patología; Ratones; Grasa Subcutánea/metabolismo; Proteína Desacopladora 1/biosíntesis; Aumento de Peso/efectos de los fármacos

Palabras clave

AMP-dependent protein kinase; DPP-4 inhibitor; Western diet; adipocyte hypertrophy; adipose inflammation; hypertrophie des adipocytes; inflammation adipeuse; inhibiteur de la DPP-4; metabolic syndrome; nonalcoholic steatohepatitis; oxidative stress; protéine kinase dépendante de l'AMP; régime alimentaire occidental; stress oxydant; stéatose hépatique non alcoolique; syndrome métabolique

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidonas / Pirimidinas / Síndrome Metabólico / Dieta Occidental Límite: Animals Idioma: En Revista: Can J Physiol Pharmacol Año: 2017 Tipo del documento: Article Pais de publicación: Canadá

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