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Tumor-targeted supramolecular nanoparticles self-assembled from a ruthenium-ß-cyclodextrin complex and an adamantane-functionalized peptide.
Xue, Shan-Shan; Tan, Cai-Ping; Chen, Mu-He; Cao, Jian-Jun; Zhang, Dong-Yang; Ye, Rui-Rong; Ji, Liang-Nian; Mao, Zong-Wan.
Afiliación
  • Xue SS; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
  • Tan CP; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
  • Chen MH; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
  • Cao JJ; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
  • Zhang DY; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
  • Ye RR; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
  • Ji LN; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
  • Mao ZW; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
Chem Commun (Camb) ; 53(5): 842-845, 2017 Jan 10.
Article en En | MEDLINE | ID: mdl-27917426
We report here a supramolecular strategy to assemble a cyclodextrin-functionalized anticancer Ru(ii) complex with an adamantane-appended tumor-targeting peptide into discrete and stable phosphorescent nanostructures that can induce cell death in integrin αvß3-rich tumor cells with high selectivity. This strategy presents new opportunities for the construction of tumor-targeting metallo-anticancer therapeutics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido