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Dysregulated Homeostasis of Acetylcholine Levels in Immune Cells of RR-Multiple Sclerosis Patients.
Di Bari, Maria; Reale, Marcella; Di Nicola, Marta; Orlando, Viviana; Galizia, Sabrina; Porfilio, Italo; Costantini, Erica; D'Angelo, Chiara; Ruggieri, Serena; Biagioni, Stefano; Gasperini, Claudio; Tata, Ada Maria.
Afiliación
  • Di Bari M; Department of Biology and Biotechnologies Charles Darwin, Research, Center of Neurobiology Daniel Bovet, Sapienza University of Rome, 00185 Rome, Italy. maria.dibari@uniroma1.it.
  • Reale M; Department of Medical, Oral and Biotechnological Science, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. mreale@unich.it.
  • Di Nicola M; Department of Medical, Oral and Biotechnological Science, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. marta.dinicola@unich.it.
  • Orlando V; Department of Biology and Biotechnologies Charles Darwin, Research, Center of Neurobiology Daniel Bovet, Sapienza University of Rome, 00185 Rome, Italy. viviana.orlando@uniroma1.it.
  • Galizia S; Department of Biology and Biotechnologies Charles Darwin, Research, Center of Neurobiology Daniel Bovet, Sapienza University of Rome, 00185 Rome, Italy. galiziasabrina1@gmail.com.
  • Porfilio I; School of Hygiene and Preventive Medicine, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. porfilioitalo@gmail.com.
  • Costantini E; Department of Medical, Oral and Biotechnological Science, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. erica.costantini@unich.it.
  • D'Angelo C; Department of Medical, Oral and Biotechnological Science, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. chiara.dangelo@unich.it.
  • Ruggieri S; Department of Neurology and Psichiatry, Sapienza University of Rome, 00185 Rome, Italy. serena.ruggieri@gmail.com.
  • Biagioni S; Department of Neurosciences, San Camillo Forlanini Hospital, 00185 Rome, Italy. serena.ruggieri@gmail.com.
  • Gasperini C; Department of Biology and Biotechnologies Charles Darwin, Research, Center of Neurobiology Daniel Bovet, Sapienza University of Rome, 00185 Rome, Italy. stefano.biagioni@uniroma1.it.
  • Tata AM; Department of Neurosciences, San Camillo Forlanini Hospital, 00185 Rome, Italy. c.gasperini@libero.it.
Int J Mol Sci ; 17(12)2016 Nov 30.
Article en En | MEDLINE | ID: mdl-27916909
Multiple sclerosis (MS) is characterized by pro-inflammatory cytokine production. Acetylcholine (ACh) contributes to the modulation of central and peripheral inflammation. We studied the homeostasis of the cholinergic system in relation to cytokine levels in immune cells and sera of relapsing remitting-MS (RR-MS) patients. We demonstrated that lower ACh levels in serum of RR-MS patients were inversely correlated with the increased activity of the hydrolyzing enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Interestingly, the expression of the ACh biosynthetic enzyme and the protein carriers involved in non-vesicular ACh release were found overexpressed in peripheral blood mononuclear cells of MS patients. The inflammatory state of the MS patients was confirmed by increased levels of TNFα, IL-12/IL-23p40, IL-18. The lower circulating ACh levels in sera of MS patients are dependent on the higher activity of cholinergic hydrolyzing enzymes. The smaller ratio of ACh to TNFα, IL-12/IL-23p40 and IL-18 in MS patients, with respect to healthy donors (HD), is indicative of an inflammatory environment probably related to the alteration of cholinergic system homeostasis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetilcolina / Esclerosis Múltiple Recurrente-Remitente Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetilcolina / Esclerosis Múltiple Recurrente-Remitente Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza