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Loss of the Opa interacting protein 5 inhibits breast cancer proliferation through miR-139-5p/NOTCH1 pathway.
Li, Hong-Chang; Chen, Ya-Feng; Feng, Wen; Cai, Han; Mei, Yi; Jiang, Yi-Ming; Chen, Teng; Xu, Ke; Feng, Dian-Xu.
Afiliación
  • Li HC; Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
  • Chen YF; Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
  • Feng W; Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
  • Cai H; Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
  • Mei Y; Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
  • Jiang YM; Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
  • Chen T; Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
  • Xu K; Central Laboratory of Putuo Hospital, Interventional Cancer Institute of Chinese Integrative Medicine, Shanghai University of Traditional Chinese Medicine, 164 Lanxi Rd, Shanghai 200062, PR China. Electronic address: cola519@163.com.
  • Feng DX; Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China. Electronic address: fdianxu@sohu.com.
Gene ; 603: 1-8, 2017 Mar 01.
Article en En | MEDLINE | ID: mdl-27916718
Opa interacting protein 5 (OIP5) has been reported to be over-expressed in several kinds of human cancer. However, the biological function and clinical significance of OIP5 in human breast cancer remains unknown. In this study, we found that OIP5 was notably over-expressed in breast cancer tissues compared with their corresponding nontumorous tissues. Statistical analysis showed a significant correlation of OIP5 expression with advanced clinical stage. Ablation OIP5 inhibited the proliferation of breast cancer cells. OIP5 over-expression inhibited hsa-miR-139-5p expression, antagonized its functions and led to the de-repression of its endogenous target NOTCH1, which was a core oncogene in promoting breast cancer progression. Our results suggested that OIP5 is a potential diagnosis biomarker and therapeutic target for breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteínas Cromosómicas no Histona / Biomarcadores de Tumor / MicroARNs / ARN Interferente Pequeño / Receptor Notch1 Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Gene Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteínas Cromosómicas no Histona / Biomarcadores de Tumor / MicroARNs / ARN Interferente Pequeño / Receptor Notch1 Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Gene Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos