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Molecular Mechanisms of Apical Periodontitis: Emerging Role of Epigenetic Regulators.
Mehrazarin, Shebli; Alshaikh, Abdullah; Kang, Mo K.
Afiliación
  • Mehrazarin S; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, CHS 43-033, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
  • Alshaikh A; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, CHS 43-033, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
  • Kang MK; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, CHS 43-033, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA; Section of Endodontics, Division of Constitutive and Regenerative Sciences, UCLA School of Dentistry, CHS 43-007, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA. Electronic address: mkang@dentistry.ucla.edu.
Dent Clin North Am ; 61(1): 17-35, 2017 01.
Article en En | MEDLINE | ID: mdl-27912817
Conventional root canal therapies yield high success rates. The treatment outcomes are negatively affected by the presence of apical periodontitis (AP), which reflects active root canal infection and inflammatory responses. Also, cross-sectional studies revealed surprisingly high prevalence of AP in the general population, especially in those with prior endodontic treatments. Hence, AP is an ongoing disease entity in endodontics that needs further understanding of the pathogenesis and disease progression. The current Chapter will discuss the basic mechanisms of AP with emphasis on emerging role of epigenetic regulators in regulation of inflammatory mediators.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis Periapical / Epigénesis Genética Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Dent Clin North Am Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis Periapical / Epigénesis Genética Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Dent Clin North Am Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos