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Meningococcal Carriage in Military Recruits and University Students during the Pre MenB Vaccination Era in Greece (2014-2015).
Tryfinopoulou, Kyriaki; Kesanopoulos, Konstantinos; Xirogianni, Athanasia; Marmaras, Nektarios; Papandreou, Anastasia; Papaevangelou, Vassiliki; Tsolia, Maria; Jasir, Aftab; Tzanakaki, Georgina.
Afiliación
  • Tryfinopoulou K; National Meningitis Reference Laboratory (NMRL), Dept of Public Health, National School of Public Health, Athens, Greece.
  • Kesanopoulos K; European Public Health Microbiology Training Programme (EUPHEM), European Centre For Disease Prevention and Control, Stockholm, Sweden.
  • Xirogianni A; National Meningitis Reference Laboratory (NMRL), Dept of Public Health, National School of Public Health, Athens, Greece.
  • Marmaras N; National Meningitis Reference Laboratory (NMRL), Dept of Public Health, National School of Public Health, Athens, Greece.
  • Papandreou A; National Meningitis Reference Laboratory (NMRL), Dept of Public Health, National School of Public Health, Athens, Greece.
  • Papaevangelou V; National Meningitis Reference Laboratory (NMRL), Dept of Public Health, National School of Public Health, Athens, Greece.
  • Tsolia M; Third Department of Paediatrics University General Hospital ATTIKON National Kapodistrian University of Athens, Athens, Greece.
  • Jasir A; Second Dept of Paediatrics "Aglaia Kyriakou" Children's Hospital, School of Medicine, National Kapodistrian University of Athens, Athens, Greece.
  • Tzanakaki G; European Public Health Microbiology Training Programme (EUPHEM), European Centre For Disease Prevention and Control, Stockholm, Sweden.
PLoS One ; 11(12): e0167404, 2016.
Article en En | MEDLINE | ID: mdl-27907129
PURPOSE: The aim of the study was to estimate the meningococcal carriage rate and to identify the genotypic characteristics of the strains isolated from healthy military recruits and university students in order to provide data that might increase our understanding on the epidemiology of meningococcus and obtain information which helps to evaluate the potential effects on control programs such as vaccination. METHODS: A total of 1420 oropharyngeal single swab samples were collected from military recruits and university students on voluntary basis, aged 18-26 years. New York City Medium was used for culture and the suspected N. meningitidis colonies were identified by Gram stain, oxidase and rapid carbohydrate utilization tests. Further characterisation was carried out by molecular methods (multiplex PCR, MLST, WGS). RESULTS: The overall carriage rate was of 12.7%; 15% and 10.4% for recruits and university students respectively. MenB (39.4%) was the most prevalent followed by MenY (12.8%) and MenW (4.4%). Among the initial 76 Non Groupable (NG) isolates, Whole Genome Sequence Analysis (WGS) revealed that 8.3% belonged to MenE, 3.3% to MenX and 1.1% to MenZ, while, 53 strains (29.4%) were finally identified as capsule null. Genetic diversity was found among the MenB isolates, with 41/44 cc and 35 cc predominating. CONCLUSION: Meningococcal carriage rate in both groups was lower compared to our previous studies (25% and 18% respectively) with predominance of MenB isolates. These findings, help to further our understanding on the epidemiology of meningococcal disease in Greece. Although the prevalence of carriage seems to have declined compared to our earlier studies, the predominant MenB clonal complexes (including 41/44cc and 35cc) are associated with invasive meningococcal disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Meningocócicas / Antígenos Bacterianos / Neisseria meningitidis Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Meningocócicas / Antígenos Bacterianos / Neisseria meningitidis Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Estados Unidos