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Background-based Delineation of Internal Tumor Volume in Static Positron Emission Tomography in a Phantom Study.
Chen, Yangchun; Chen, Xiangrong; Liu, Ji-An; Li, Fanyong.
Afiliación
  • Chen Y; Department of Nuclear Medicine, Quanzhou First Hospital, Fujian Medical University, Quanzhou, China; The PET-CT Center, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Chen X; Department of Radiology, Quanzhou First Hospital, Fujian Medical University, Quanzhou, China.
  • Liu JA; Guangdong Provincial Key Laboratory of Micro-nano Manufacturing Technology and Equipment, Guangdong University of Technology, Guangzhou, China.
  • Li F; The PET-CT Center, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Asia Ocean J Nucl Med Biol ; 4(1): 38-44, 2016.
Article en En | MEDLINE | ID: mdl-27904872
OBJECTIVES: Considering the fact that the standardized uptake value (SUV) of a normal lung tissue is expressed as x±SD, x+3×SD could be considered as the threshold value to outline the internal tumor volume (ITV) of a lung neoplasm. METHODS: Three hollow models were filled with 55.0 kBq/mL fluorine-18 fluorodeoxyglucose (18F-FDG) to represent tumors. The models were fixed to a barrel filled with 5.9 kBq/mL 18F-FDG to characterize normal lung tissues as a phantom. The PET/CT images of the phantom were acquired at rest. Then, the barrel was moved periodically to simulate breathing while acquiring PET/CT data. Volume recovery coefficient (VRC) was applied to evaluate the accuracy of ITVs. For statistical analysis, paired t-test and analysis of variance were applied. RESULTS: The VRCs ranged from 0.74 to 0.98 and significantly varied among gross tumor volumes for delineating ITV (P<0.01). In two-dimensional PET scans, the motion distance did not affect VRC (P>0.05), whereas VRC decreased with increasing distance in three-dimensional PET scans (P<0.05). CONCLUSION: The threshold value (x+3×SD) had the potential to delineate the ITV of cancerous tissues, surrounded by lung tissues, particularly in two-dimensional PET images.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Asia Ocean J Nucl Med Biol Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Irán
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Asia Ocean J Nucl Med Biol Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Irán