Your browser doesn't support javascript.
loading
Spontaneous Assembly of an Organic-Inorganic Nucleic Acid Z-DNA Double-Helix Structure.
Kulikov, Vladislav; Johnson, Naomi A B; Surman, Andrew J; Hutin, Marie; Kelly, Sharon M; Hezwani, Mohammed; Long, De-Liang; Meyer, Gerd; Cronin, Leroy.
Afiliación
  • Kulikov V; The University of Glasgow, WestChem, School of Chemistry, Joseph Black Building, Glasgow, G12 8QQ, UK.
  • Johnson NA; The University of Glasgow, WestChem, School of Chemistry, Joseph Black Building, Glasgow, G12 8QQ, UK.
  • Surman AJ; The University of Glasgow, WestChem, School of Chemistry, Joseph Black Building, Glasgow, G12 8QQ, UK.
  • Hutin M; The University of Glasgow, WestChem, School of Chemistry, Joseph Black Building, Glasgow, G12 8QQ, UK.
  • Kelly SM; The University of Glasgow, Institute of Molecular Cell and Systems Biology, Joseph Black Building, Glasgow, G12 8QQ, UK.
  • Hezwani M; The University of Glasgow, WestChem, School of Chemistry, Joseph Black Building, Glasgow, G12 8QQ, UK.
  • Long DL; The University of Glasgow, WestChem, School of Chemistry, Joseph Black Building, Glasgow, G12 8QQ, UK.
  • Meyer G; Universität zu Köln, Institut für Anorganische Chemie, Greinstrasse 6, 50939, Köln, Germany.
  • Cronin L; Iowa State University, Department of Chemistry, Ames, Iowa, 50011, USA.
Angew Chem Int Ed Engl ; 56(4): 1141-1145, 2017 01 19.
Article en En | MEDLINE | ID: mdl-27900812
Herein, we report a hybrid polyoxometalate organic-inorganic compound, Na2 [(HGMP)2 Mo5 O15 ]⋅7 H2 O (1; where GMP=guanosine monophosphate), which spontaneously assembles into a structure with dimensions that are strikingly similar to those of the naturally occurring left-handed Z-form of DNA. The helical parameters in the crystal structure of the new compound, such as rise per turn and helical twist per dimer, are nearly identical to this DNA conformation, allowing a close comparison of the two structures. Solution circular dichroism studies show that compound 1 also forms extended secondary structures in solution. Gel electrophoresis studies demonstrate the formation of non-covalent adducts with natural plasmids. Thus we show a route by which simple hybrid inorganic-organic monomers, such as compound 1, can spontaneously assemble into a double helix without the need for a covalently connected linear sequence of nucleic acid base pairs.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organometálicos / ADN de Forma Z Idioma: En Revista: Angew Chem Int Ed Engl Año: 2017 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organometálicos / ADN de Forma Z Idioma: En Revista: Angew Chem Int Ed Engl Año: 2017 Tipo del documento: Article Pais de publicación: Alemania