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Maternal high-fat diet prevents developmental programming by early-life stress.
Rincel, M; Lépinay, A L; Delage, P; Fioramonti, J; Théodorou, V S; Layé, S; Darnaudéry, M.
Afiliación
  • Rincel M; INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France.
  • Lépinay AL; Université de Bordeaux, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France.
  • Delage P; INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France.
  • Fioramonti J; Université de Bordeaux, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France.
  • Théodorou VS; INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France.
  • Layé S; Université de Bordeaux, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France.
  • Darnaudéry M; INRA, Toxalim, UMR1331, Toulouse, France.
Transl Psychiatry ; 6(11): e966, 2016 11 29.
Article en En | MEDLINE | ID: mdl-27898075
Anxiety disorders and depression are well-documented in subjects exposed to adverse childhood events. Recently, maternal obesity and/or maternal consumption of high-fat diets (HFD) have been also proposed as risk factors for offspring mental health. Here using an animal model in rats, we explored the combinatorial effects of a maternal HFD (40% of energy from fat without impact on maternal weight; during gestation and lactation) and maternal separation (MS) in offspring. In the prefrontal cortex (PFC) of pups, MS led to changes in the expression of several genes such as Bdnf (brain derived neurotrophic factor), 5HT-r1a (serotonin receptor 1a) and Rest4 (neuron-restrictive silencer element, repressor element 1, silencing transcription factor (Rest), splicing variant 4). Surprisingly, perinatal HFD strongly attenuated the developmental alterations induced by MS. Furthermore, maternal HFD totally prevented the endophenotypes (anxiety, spatial memory, social behavior, hypothalamic-pituitary-adrenal (HPA) axis response to stress, hippocampal neurogenesis and visceral pain) associated with MS at adulthood. Finally, we also demonstrated that HFD intake reduced anxiety and enhanced maternal care in stressed dams. Overall, our data suggest that a HFD restricted to gestation and lactation, which did not lead to overweight in dams, had limited effects in unstressed offspring, highlighting the role of maternal obesity, rather than fat exposure per se, on brain vulnerability during development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Modelos Animales de Enfermedad / Acontecimientos que Cambian la Vida Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Pregnancy Idioma: En Revista: Transl Psychiatry Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Modelos Animales de Enfermedad / Acontecimientos que Cambian la Vida Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Pregnancy Idioma: En Revista: Transl Psychiatry Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos