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The relationship between oestrogen and executive functioning in ALS females with emerging Frontotemporal Lobar Degeneration (FTLD) supports a neuroendocrine model of FTLD attenuation.
Flaherty, C; Kraft, J; Brothers, A; Harrison, M; Legro, R S; Manni, A; Yang, C; Simmons, Z.
Afiliación
  • Flaherty C; a Department of Neurology , Penn State College of Medicine , Hershey , PA , USA.
  • Kraft J; b Department of Psychology , Penn State University , Middletown , PA , USA.
  • Brothers A; c Department of Human Development and Family Studies , Colorado State University , Fort Collins , CO , USA.
  • Harrison M; b Department of Psychology , Penn State University , Middletown , PA , USA.
  • Legro RS; d Department of OB/GYN , Penn State College of Medicine , Hershey , PA , USA.
  • Manni A; e Division of Endocrinology, Diabetes and Metabolism , Penn State College of Medicine , Hershey , PA , USA , and.
  • Yang C; f Department of Public Health Sciences , Penn State College of Medicine , Hershey , PA , USA.
  • Simmons Z; a Department of Neurology , Penn State College of Medicine , Hershey , PA , USA.
Amyotroph Lateral Scler Frontotemporal Degener ; 18(1-2): 74-85, 2017 Feb.
Article en En | MEDLINE | ID: mdl-27892698
OBJECTIVE: The prevalence of ALS cognitive or behavioural impairment (ci or bi) consistent with Frontotemporal Degeneration (FTLD) approachs 50%, while ∼5-10% progress to dementia. Our goal was to explore ci and bi differencs between bulbar and limb onset, as well as the neuroprotective potential of oestrogen in emerging FTLD. METHODS: We applied Mann Whitney U to evaluate differences in cognitive and behavioural profiles between site of onset in 78 female and 83 male non-demented ALS participants classified by current consensus criteria with ci. For females, we also examined differences by oestrogen level. FINDINGS: Between group analyses found significantly worse Letter Fluency (LF) for bulbar onset, and worse Category Fluency (CF) for bulbar females. Significantly worse performance was found for low oestrogen females for LF and Similarities, with significantly worse LF for low oestrogen bulbar onset. No significant differences were found for behavioural subgroups, while moderate-severe range traits were higher in occurrence for bulbar and low oestrogen bulbar onset. CONCLUSIONS: Findings support our previously published mesocortical pathway associated "bottom-up" model of FTLD emergence in ALSbi, extending it with a hierarchal hypothesis involving ascending cerebellar pathways in ALSci and ALSbi, further suggesting a role for oestrogen in mitigating female FTLD progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caracteres Sexuales / Trastornos del Conocimiento / Estrógenos / Degeneración Lobar Frontotemporal / Función Ejecutiva / Esclerosis Amiotrófica Lateral Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Amyotroph Lateral Scler Frontotemporal Degener Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caracteres Sexuales / Trastornos del Conocimiento / Estrógenos / Degeneración Lobar Frontotemporal / Función Ejecutiva / Esclerosis Amiotrófica Lateral Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Amyotroph Lateral Scler Frontotemporal Degener Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido