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Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths.
Gabrie, José Antonio; Rueda, María Mercedes; Rodríguez, Carol Anahelka; Canales, Maritza; Sanchez, Ana Lourdes.
Afiliación
  • Gabrie JA; Department of Health Sciences, Brock University, St. Catharines, ON, Canada.
  • Rueda MM; School of Microbiology, National Autonomous University of Honduras (UNAH), Tegucigalpa, Honduras.
  • Rodríguez CA; School of Microbiology, National Autonomous University of Honduras (UNAH), Tegucigalpa, Honduras.
  • Canales M; School of Microbiology, National Autonomous University of Honduras (UNAH), Tegucigalpa, Honduras.
  • Sanchez AL; Department of Health Sciences, Brock University, St. Catharines, ON, Canada; Microbiology Research Institute, National Autonomous University of Honduras (UNAH), Tegucigalpa, Honduras.
J Parasitol Res ; 2016: 1769585, 2016.
Article en En | MEDLINE | ID: mdl-27882241
Soil-transmitted helminth infections typically induce a type-2 immune response (Th2), but no immunoepidemiological studies have been undertaken in Honduras, an endemic country where the main control strategy is children's annual deworming. We aimed to characterize the immune profile of Honduran schoolchildren harbouring these parasitoses. Demographic and epidemiological data were obtained through a survey; nutritional status was assessed through anthropometry; intestinal parasites were diagnosed by formol-ether and Kato-Katz; and blood samples were collected to determine immunological markers including Th1/Th2 cytokines, IgE, and eosinophil levels. A total of 225 children participated in the study, all of whom had received deworming during the national campaign five months prior to the study. Trichuriasis and ascariasis prevalence were 22.2% and 20.4%, respectively. Stunting was associated with both age and trichuriasis, whereas ascariasis was associated with sex and household conditions. Helminth infections were strongly associated with eosinophilia and hyper-IgE as well as with a Th2-polarized response (increased levels of IL-13, IL-10, and IL4/IFN-γ ratios and decreased levels of IFN-γ). Pathogenic protozoa infections were associated with a Th1 response characterized by elevated levels of IFN-γ and decreased IL10/IFN-γ ratios. Even at low prevalence levels, STH infections affect children's nutrition and play a polarizing role in their immune system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Parasitol Res Año: 2016 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Parasitol Res Año: 2016 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos