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A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding.
Douthwaite, Julie; Moisan, Jacques; Privezentzev, Cyril; Soskic, Blagoje; Sabbah, Shereen; Cohen, Suzanne; Collinson, Andie; England, Elizabeth; Huntington, Catherine; Kemp, Ben; Zhuang, Li; Hudak, Suzanne; Rees, D Gareth; Goldberg, Debbie; Barton, Chris; Chang, Linda; Vainshtein, Inna; Liang, Meina; Iciek, Laurie; Ambery, Philip; Peakman, Mark; Vaughan, Tristan J; Tree, Tim I M; Sansom, David M; Bowen, Michael A; Minter, Ralph R; Jermutus, Lutz.
Afiliación
  • Douthwaite J; MedImmune, Cambridge CB21 6GH, United Kingdom.
  • Moisan J; MedImmune, Gaithersburg, MD 20878.
  • Privezentzev C; MedImmune, Cambridge CB21 6GH, United Kingdom.
  • Soskic B; Royal Free Campus, Institute of Immunity and Transplantation, University College London, London NW3 2PF, United Kingdom.
  • Sabbah S; Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.
  • Cohen S; Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, United Kingdom.
  • Collinson A; National Institutes of Health Research Biomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust, London SE1 9RT, United Kingdom; and.
  • England E; MedImmune, Cambridge CB21 6GH, United Kingdom.
  • Huntington C; MedImmune, Cambridge CB21 6GH, United Kingdom.
  • Kemp B; MedImmune, Cambridge CB21 6GH, United Kingdom.
  • Zhuang L; MedImmune, Cambridge CB21 6GH, United Kingdom.
  • Hudak S; MedImmune, Cambridge CB21 6GH, United Kingdom.
  • Rees DG; MedImmune, Gaithersburg, MD 20878.
  • Goldberg D; MedImmune, Gaithersburg, MD 20878.
  • Barton C; MedImmune, Cambridge CB21 6GH, United Kingdom.
  • Chang L; MedImmune, Gaithersburg, MD 20878.
  • Vainshtein I; MedImmune, Gaithersburg, MD 20878.
  • Liang M; MedImmune, Mountain View, CA 94043.
  • Iciek L; MedImmune, Mountain View, CA 94043.
  • Ambery P; MedImmune, Mountain View, CA 94043.
  • Peakman M; MedImmune, Gaithersburg, MD 20878.
  • Vaughan TJ; MedImmune, Cambridge CB21 6GH, United Kingdom.
  • Tree TI; Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.
  • Sansom DM; Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, United Kingdom.
  • Bowen MA; National Institutes of Health Research Biomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust, London SE1 9RT, United Kingdom; and.
  • Minter RR; MedImmune, Cambridge CB21 6GH, United Kingdom.
  • Jermutus L; Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.
J Immunol ; 198(1): 528-537, 2017 01 01.
Article en En | MEDLINE | ID: mdl-27881707
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Abatacept / Inmunosupresores Límite: Animals / Humans Idioma: En Revista: J Immunol Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Abatacept / Inmunosupresores Límite: Animals / Humans Idioma: En Revista: J Immunol Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos