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MCR: modern colistin resistance.
Caniaux, I; van Belkum, A; Zambardi, G; Poirel, L; Gros, M F.
Afiliación
  • Caniaux I; Medical Affairs, bioMérieux SA, 376, Chemin de l'Orme, 69280, Marcy L'Etoile, France.
  • van Belkum A; Scientific Office, bioMérieux SA, 3, Route de Port Michaud, 38390, La Balme-les-Grottes, France.
  • Zambardi G; Scientific Office, bioMérieux SA, 3, Route de Port Michaud, 38390, La Balme-les-Grottes, France.
  • Poirel L; Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Rue Albert Gockel 3, 1700, Fribourg, Switzerland.
  • Gros MF; INSERM European Unit (LEA, IAME, France), University of Fribourg, Fribourg, Switzerland.
Eur J Clin Microbiol Infect Dis ; 36(3): 415-420, 2017 Mar.
Article en En | MEDLINE | ID: mdl-27873028
Recently, plasmid-mediated and, therefore, transferable bacterial polymyxin resistance was discovered in strains from both humans and animals. Such a trait may widely spread geographically, while simultaneously crossing microbial species barriers. This may ultimately render the "last resort" polymyxin antibiotics therapeutically useless. Colistin is currently used to treat infections caused by Gram-negative carbapenemase producers and colistin resistance may lead to practical pan-antibiotic resistance. We here analyzed the medical and diagnostic consequences of (emerging) colistin resistance and propose pathways toward adequate diagnostics for timely detection of both asymptomatic carriage and infection. Culture-based testing using chromogenic and selective media for screening clinical (and veterinary) specimens may constitute key tools for that purpose. Relevant molecular tests are also discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Bacterias Gramnegativas / Colistina / Farmacorresistencia Bacteriana / Bacterias Gramnegativas / Antibacterianos Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Eur J Clin Microbiol Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Bacterias Gramnegativas / Colistina / Farmacorresistencia Bacteriana / Bacterias Gramnegativas / Antibacterianos Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Eur J Clin Microbiol Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania