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Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons.
Jang, Eun-Hae; Sim, Aeri; Im, Sun-Kyoung; Hur, Eun-Mi.
Afiliación
  • Jang EH; Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea; Department of Neuroscience, Korea University of Science and Technology, Daejeon, Republic of Korea; Convergence Research Center for Diagnosis, Treatment and Care System of De
  • Sim A; Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea; Department of Neuroscience, Korea University of Science and Technology, Daejeon, Republic of Korea; Convergence Research Center for Diagnosis, Treatment and Care System of De
  • Im SK; Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
  • Hur EM; Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea; Department of Neuroscience, Korea University of Science and Technology, Daejeon, Republic of Korea; Convergence Research Center for Diagnosis, Treatment and Care System of De
Neural Plast ; 2016: 5056418, 2016.
Article en En | MEDLINE | ID: mdl-27872763
Several studies have demonstrated the therapeutic potential of applying microtubule- (MT-) stabilizing agents (MSAs) that cross the blood-brain barrier to promote axon regeneration and prevent axonal dystrophy in rodent models of spinal cord injury and neurodegenerative diseases. Paradoxically, administration of MSAs, which have been widely prescribed to treat malignancies, is well known to cause debilitating peripheral neuropathy and axon degeneration. Despite the growing interest of applying MSAs to treat the injured or degenerating central nervous system (CNS), consequences of MSA exposure to neurons in the central and peripheral nervous system (PNS) have not been thoroughly investigated. Here, we have examined and compared the effects of a brain-penetrant MSA, epothilone B, on cortical and sensory neurons in culture and show that epothilone B exhibits both beneficial and detrimental effects, depending on not only the concentration of drug but also the type and age of a neuron, as seen in clinical settings. Therefore, to exploit MSAs to their full benefit and minimize unwanted side effects, it is important to understand the properties of neuronal MTs and strategies should be devised to deliver minimal effective concentration directly to the site where needed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epotilonas / Moduladores de Tubulina / Microtúbulos / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neural Plast Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epotilonas / Moduladores de Tubulina / Microtúbulos / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neural Plast Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos