Your browser doesn't support javascript.
loading
Metabotropic glutamate receptors and neurodegenerative diseases.
Ribeiro, Fabiola M; Vieira, Luciene B; Pires, Rita G W; Olmo, Roenick P; Ferguson, Stephen S G.
Afiliación
  • Ribeiro FM; Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.
  • Vieira LB; Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.
  • Pires RG; Department of Physiological Sciences, Health Science Center, Universidade Federal do Espirito Santo, Vitoria, 29043-910, Brazil.
  • Olmo RP; Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.
  • Ferguson SS; University of Ottawa Brain and Mind Institute and Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, K1H 8M5, Canada. Electronic address: sferguso@uottawa.ca.
Pharmacol Res ; 115: 179-191, 2017 01.
Article en En | MEDLINE | ID: mdl-27872019
Glutamate is the most important excitatory neurotransmitter of the mammalian central nervous system (CNS), playing an important role in memory, synaptic plasticity and neuronal development. However, glutamate overstimulation is also implicated in neuronal cell death. There are two major types of glutamate receptors: ionotropic and metabotropic. Thus far, eight metabotropic glutamate receptors (mGluRs) subtypes have been characterized and are divided into three subgroups based on sequence homology and cell signaling activation. mGluRs activate a wide variety of cell signaling pathways by G protein-coupled pathways or via G protein-independent cell signaling activation. Moreover, these receptors exhibit widespread distribution in the CNS and are implicated in several neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). This review aims to discuss the latest updates concerning mGluRs and their role in neurodegenerative diseases. mGluRs agonists and antagonists as well as positive and negative allosteric modulators have been tested in several animal models of neurodegenerative diseases. Furthermore, mGluR knockout mouse models have been crossed to mouse models of AD and HD, providing important data about mGluRs role in neurodegenerative disease progression. Thus, mGluRs constitute potential therapeutic targets for the development of therapies to treat neurodegenerative diseases.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Glutamato Metabotrópico / Enfermedades Neurodegenerativas Límite: Animals / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Glutamato Metabotrópico / Enfermedades Neurodegenerativas Límite: Animals / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos