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Safflower (Catharmus tinctorius L.) oil supplementation in overnourished rats during early neonatal development: effects on heart and liver function in the adult.
Costa, Laís Ribeiro; Macêdo, Patrícia Cavalcanti; de Melo, Janatar Stella Vasconcelos; Freitas, Cristiane Moura; Alves, Aiany Simoes; Barbosa, Humberto de Moura; Lira, Eduardo; Fernandes, Mariana Pinheiro; Batista-de-Oliveira-Hornsby, Manuella; Lagranha, Claudia.
Afiliación
  • Costa LR; a Department of Nutrition/Centro de Ciencias da Saude (CCS). Federal University of Pernambuco, Campus of Recife, Recife, PE 55608-680, Brazil.
  • Macêdo PC; a Department of Nutrition/Centro de Ciencias da Saude (CCS). Federal University of Pernambuco, Campus of Recife, Recife, PE 55608-680, Brazil.
  • de Melo JS; a Department of Nutrition/Centro de Ciencias da Saude (CCS). Federal University of Pernambuco, Campus of Recife, Recife, PE 55608-680, Brazil.
  • Freitas CM; b Laboratory of Biochemistry and Exercise Biochemistry, Federal University of Pernambuco, Campus of Vitoria de Santo Antao, Vitoria de Santo Antao, PE, Brazil.
  • Alves AS; b Laboratory of Biochemistry and Exercise Biochemistry, Federal University of Pernambuco, Campus of Vitoria de Santo Antao, Vitoria de Santo Antao, PE, Brazil.
  • Barbosa HM; c Department of Physiology and Pharmacology/Centro de Ciências Biológicas (CCB), Federal University of Pernambuco, Campus of Recife, Recife, PE, Brazil.
  • Lira E; c Department of Physiology and Pharmacology/Centro de Ciências Biológicas (CCB), Federal University of Pernambuco, Campus of Recife, Recife, PE, Brazil.
  • Fernandes MP; b Laboratory of Biochemistry and Exercise Biochemistry, Federal University of Pernambuco, Campus of Vitoria de Santo Antao, Vitoria de Santo Antao, PE, Brazil.
  • Batista-de-Oliveira-Hornsby M; a Department of Nutrition/Centro de Ciencias da Saude (CCS). Federal University of Pernambuco, Campus of Recife, Recife, PE 55608-680, Brazil.
  • Lagranha C; b Laboratory of Biochemistry and Exercise Biochemistry, Federal University of Pernambuco, Campus of Vitoria de Santo Antao, Vitoria de Santo Antao, PE, Brazil.
Appl Physiol Nutr Metab ; 41(12): 1271-1277, 2016 Dec.
Article en En | MEDLINE | ID: mdl-27863203
Carthamus tinctorius L. (common name: safflower) is an herb whose extracted oil (safflower oil) has been employed in both alternative and conventional medicine in the treatment of disease. Overnutrition during early postnatal life can increase the lifetime risk of obesity and metabolic syndrome. Here we investigate the effect of safflower oil supplementation given during a critical early developmental stage on the eventual occurrence of metabolic disease in overnourished rats. Groups of overnourished or adequately nourished rats were randomly assigned into 2 additional groups for supplementation with either safflower oil (SF) or vehicle for 7 to 30 days. Murinometric data and weights were examined. Serum was collected for measurement of glucose, cholesterol, high-density lipoprotein cholesterol, and triglycerides. Heart and liver oxidative status were also measured. Overnutrition for 7-30 days induced a significant increase in body weight and in values for abdominal circumference, thoracic circumference, body length, and body mass index. SF supplementation did not attenuate the effect of overnutrition on any of these parameters. In addition, overnutrition increased levels of glucose, triglycerides, and very low-density lipid compared with normal controls, but SF supplementation had no effect on these parameters. Measures of oxidative status in heart or liver were not influenced by overnutrition. However, oxidative measures were altered by SF supplementation in both of these organs. The present study reveals that nutritional manipulation during early development induces detrimental effects on metabolism in the adult that are not ameliorated by supplemental SF.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceite de Cártamo / Estrés Oxidativo / Carthamus tinctorius / Hipernutrición / Ácidos Grasos Omega-6 / Hígado / Miocardio Tipo de estudio: Etiology_studies Límite: Animals / Pregnancy Idioma: En Revista: Appl Physiol Nutr Metab Asunto de la revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / MEDICINA ESPORTIVA / METABOLISMO Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Canadá
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceite de Cártamo / Estrés Oxidativo / Carthamus tinctorius / Hipernutrición / Ácidos Grasos Omega-6 / Hígado / Miocardio Tipo de estudio: Etiology_studies Límite: Animals / Pregnancy Idioma: En Revista: Appl Physiol Nutr Metab Asunto de la revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / MEDICINA ESPORTIVA / METABOLISMO Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Canadá