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Intraventricular Hemorrhage and Platelet Indices in Extremely Premature Neonates.
Mitsiakos, Georgios; Papathanasiou, Aimilia-E; Kyriakidis, Ioannis; Karagianni, Paraskevi; Tsepis, Konstantinos; Tzimou, Irene; Lazaridou, Eleni; Chatziioannidis, Ilias.
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  • Mitsiakos G; 2nd Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University, Papageorgiou General Hospital, Thessaloniki, Greece.
J Pediatr Hematol Oncol ; 38(7): 533-538, 2016 10.
Article en En | MEDLINE | ID: mdl-27849673
Intraventricular hemorrhage (IVH) is a multifactorial disorder, the most important risk factors of which are prematurity and low birth weight. Disturbances in cerebral blood flow, inherent fragility of the germinal matrix vasculature, and platelet/coagulation disturbances are the 3 major pathogenic mechanisms. In this context, we investigated the role of platelet indices and several maternal and neonatal characteristics in the development of IVH through a retrospective cohort analysis of 130 extremely premature neonates, 24% of whom presented with severe IVH. There was a significant difference in platelet counts between the IVH and the control group on the first day of life (P=0.046). Presence of IVH was linked with lower birth weight (P=0.006) and lower gestational age (P=0.001). Platelet count on the first day of life was positively correlated with survival (P=0.001) and, along with platelet mass, was indicative of the worst IVH grade recorded for each neonate (P=0.002 and 0.007, respectively). Prolonged prothrombin time was also correlated with IVH (P<0.001), but factor analysis supported no prominent role. Maternal medications seem to play a minor role as well. In conclusion, IVH in extremely premature infants cannot be solely explained by platelet parameters, and further studies are required to determine the relationships between IVH, platelet indices, and outcomes.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Cerebral / Recien Nacido Extremadamente Prematuro Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Newborn Idioma: En Revista: J Pediatr Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Cerebral / Recien Nacido Extremadamente Prematuro Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Newborn Idioma: En Revista: J Pediatr Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Estados Unidos