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Association of serum bactericidal antibody and opsonic antibody levels after Neisseria meningitidis serogroup C conjugate vaccine in Brazilian children and adolescents infected or not infected with HIV.
Pereira-Manfro, Wânia F; Alvino, Raquel M; Cruz, Aline C; Silva, Giselle P; Castro, Raquel B N; Ferreira, Bianca; Barreto, Daniella M; Frota, Ana Cristina C; Hofer, Cristina B; Milagres, Lucimar G.
Afiliación
  • Pereira-Manfro WF; State University of Rio de Janeiro, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro, Brazil. Electronic address: ferrazwp@yahoo.com.br.
  • Alvino RM; State University of Rio de Janeiro, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro, Brazil.
  • Cruz AC; State University of Rio de Janeiro, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro, Brazil.
  • Silva GP; State University of Rio de Janeiro, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro, Brazil.
  • Castro RB; State University of Rio de Janeiro, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro, Brazil.
  • Ferreira B; Instituto de Puericultura e Pediatria Martagão Gesteira, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Barreto DM; Instituto de Puericultura e Pediatria Martagão Gesteira, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Frota AC; Instituto de Puericultura e Pediatria Martagão Gesteira, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Hofer CB; Instituto de Puericultura e Pediatria Martagão Gesteira, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Preventive Medicine Department, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Milagres LG; State University of Rio de Janeiro, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro, Brazil.
Vaccine ; 34(50): 6116-6119, 2016 12 07.
Article en En | MEDLINE | ID: mdl-27847176
Neisseria meningitidis serogroup C (MenC) is the main causative agent of meningitis in Brazil. HIV infection affects the quality of the immune system. HIV+ children have an increased risk of infection to encapsulated bacteria such as N. meningitidis. We evaluated the opsonic antibody (OPA) levels and its correlation with serum bactericidal antibody (SBA) levels induced by one and two doses of a MenC conjugate vaccine in children and adolescents HIV+ and HIV-exposed but uninfected children (HEU) group. Overall the data show the importance of two doses of vaccine for HIV+ individuals. About 79% and 58% of HIV+ patients showed SBA and OPA positive response after two doses of vaccine, respectively. For HEU group, 62% and 41% of patients showed SBA and OPA positive response after one dose of vaccine, respectively. A positive and significant association between SBA and OPA levels was seen after two doses of vaccine in HIV+ patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Actividad Bactericida de la Sangre / Proteínas Opsoninas / Vacunas Meningococicas / Neisseria meningitidis Serogrupo C / Infecciones Meningocócicas / Anticuerpos Antibacterianos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Vaccine Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Actividad Bactericida de la Sangre / Proteínas Opsoninas / Vacunas Meningococicas / Neisseria meningitidis Serogrupo C / Infecciones Meningocócicas / Anticuerpos Antibacterianos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Vaccine Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos