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Case Report of the positive exostosin-1 without B-cell lymphoma-2 gene expression of giant cell tumor lesion in hereditary multiple exostosis.
Eka Wiratnaya, I Gede; Aditya Gitapradita B, Nyoman Gede; Yudhi Setiawan, I G N; Suyasa, I Ketut; Siki Kawiyana, I Ketut; Astawa, Putu.
Afiliación
  • Eka Wiratnaya IG; Orthopaedic Surgeon at Department of Orthopaedic and Traumatology, Medical Faculty, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia. Electronic address: ekawiratnaya@gmail.com.
  • Aditya Gitapradita B NG; Orthopaedic Resident at Department of Orthopaedic and Traumatology, Medical Faculty, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia.
  • Yudhi Setiawan IGN; Orthopaedic Resident at Department of Orthopaedic and Traumatology, Medical Faculty, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia.
  • Suyasa IK; Chief of Orthopaedic and Traumatology Department at Sanglah General Hospital, Medical Faculty, Udayana University, Denpasar, Bali, Indonesia.
  • Siki Kawiyana IK; Professor at Orthopaedic and Traumatology Department at Sanglah General Hospital, Medical Faculty, Udayana University, Denpasar, Bali, Indonesia.
  • Astawa P; Professor at Orthopaedic and Traumatology Department at Sanglah General Hospital, Medical Faculty, Udayana University, Denpasar, Bali, Indonesia.
Int J Surg Case Rep ; 29: 141-145, 2016.
Article en En | MEDLINE | ID: mdl-27846455
INTRODUCTION: The giant cell tumor, in which BCL-2 gene was expressed only in its malignant transformation, is a benign, primary skeletal neoplasm with variable biologic aggressiveness. The is of the giant cell tumor. A coexistence with hereditary multiple exostosis with expression of EXT-1 is very rare. The correlation between giant cell tumor in hereditary multiple exostosis is still not clearly determined. PRESENTATION OF CASE: A 31-years-old female presented with pain and lump on her left wrist and a coexistence of non tender multiple lump in the right and left knee. A wide excision of the tumor and reconstruction using non vascularized fibular graft was performed, followed by histopathology and immunohistochemistry of EXT-1 and BCL-2. DISCUSSION: In this case, the tumor showed negative BCL-2 and positive EXT-1 gene expression. Giant cell tumor and hereditary multiple exostosis also demonstrated associations of chromosomes 11 with a different pathological process. CONCLUSION: Giant cell tumor in hereditary multiple exostosis revealed positive EXT-1 without BCL-2 expression. It still need more investigation to confirm the relationship between these tumors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Surg Case Rep Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Surg Case Rep Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos